Anti-Human FRS2 Antibody Pair

Product Description: Fibroblast growth factor receptor substrate 2 (FRS2) is an 80 kDa membrane-anchored signal transducing adaptor protein that plays a crucial role in linking activated receptor tyrosine kinases (RTKs) to various downstream signaling pathways, including the MAPK/ERK and PI3K/AKT/mTOR pathways. This protein is encoded by the FRS2 gene in humans and is essential for mediating cellular responses to fibroblast growth factors (FGFs) and nerve growth factor (NGF) receptors. Its properties include the ability to interact with multiple signaling molecules, thereby modulating critical cellular functions like proliferation and differentiation. Dysregulation of FRS2 has been implicated in various diseases, including pigmentation disorders and certain types of cancer, such as prostate cancer. Protein Function: Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1 [The Uniprot Consortium]