Anti-Human FMN1 Antibody Pair

Product Description: Formin 1 (FMN1), is a multidomain protein that plays a crucial role in the regulation of the actin and microtubule cytoskeleton, impacting essential cellular processes such as cell polarity, migration, and cytokinesis. FMN1 contains several conserved domains, including the formin homology domains FH1 and FH2, which are central to its ability to promote actin filament polymerization and interact with actin-binding proteins like profilin. The FH2 domain enables FMN1 to nucleate actin filaments and associate with the barbed end, while additional domains facilitate interactions with signaling molecules and proper subcellular localization. FMN1 is also involved in the formation of adherens junctions and the assembly of linear actin cables, contributing to cell-cell adhesion and tissue integrity. Mutations in FMN1 have been linked to limb deformities in animal models, highlighting its importance in developmental processes and suggesting a role in congenital limb malformations in humans. Protein Function: Plays a role in the formation of adherens junction and the polymerization of linear actin cables [The Uniprot Consortium]