Anti-Human FES Antibody Pair

Product Description: Tyrosine-protein kinase Fes/Fps (FES) is a non-receptor tyrosine kinase that plays a significant role in various cellular processes, including cell proliferation, differentiation, and survival. FES is primarily expressed in hematopoietic cells and is involved in signaling pathways that regulate immune responses and inflammation. Its activation is associated with the regulation of cytoskeletal dynamics and cellular adhesion, which are crucial for normal immune function. Dysregulation of FES has been implicated in several diseases, such as leukemia and lymphoma. Elevated FES expression has been observed in acute myeloid leukemia (AML), where it may contribute to oncogenic signaling and promote tumor cell survival. Additionally, FES has been linked to autoimmune diseases, including rheumatoid arthritis, where its activity can exacerbate inflammation and joint damage. Protein Function: Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28 [The Uniprot Consortium]