Anti-Human FCGR3B Antibody Pair

Product Description: Fc gamma receptor IIIb (FCGR3B), also known as CD16b, is a glycosylphosphatidylinositol (GPI)-anchored membrane protein uniquely expressed on human neutrophils and eosinophils. Unlike other Fc gamma receptors, FCGR3B lacks a cytoplasmic signaling domain and instead acts primarily as a decoy receptor, modulating immune responses by binding to the Fc portion of immunoglobulin G (IgG) and facilitating the clearance of immune complexes. Structurally, it contains two extracellular immunoglobulin-like domains and exists in two main allotypic forms, NA1 and NA2, which differ in their affinity for IgG1 and IgG3, the NA1 variant is more efficient at mediating the ingestion of opsonized particles. Functionally, FCGR3B is involved in actin polymerization, beta1 integrin activation, and the formation of neutrophil extracellular traps (NETs), but does not promote phagocytosis or L-selectin expression like its counterpart FCGR2A. Clinically, genetic variations or deficiencies in FCGR3B are associated with increased susceptibility to autoimmune diseases such as systemic lupus erythematosus and certain neutrophil-mediated disorders. Protein Function: Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils [The Uniprot Consortium]