Anti-Human F8 Antibody Pair

Product Description: Coagulation factor VIII (FVIII) is a crucial protein in the blood clotting process. It is produced primarily in the liver and circulates in the bloodstream bound to von Willebrand factor. When activated, FVIII acts as a cofactor for factor IX, catalyzing the activation of factor X and ultimately leading to fibrin clot formation. Mutations in the F8 gene, which encodes FVIII, can result in hemophilia A, the most common form of this bleeding disorder. Over 1,300 different mutations have been identified, ranging from single base pair changes to large inversions. These mutations can lead to reduced FVIII production or abnormal protein function, impairing the blood clotting process and causing excessive bleeding. Conversely, elevated FVIII levels have been associated with increased risk of venous thromboembolism and may be an independent risk factor for arterial thrombotic diseases such as myocardial infarction and stroke. Protein Function: Factor VIII, along with calcium and phospholipid, acts as a cofactor for F9/factor IXa when it converts F10/factor X to the activated form, factor Xa [The Uniprot Consortium]