Anti-Human EN2 Antibody Pair

Product Description: Homeobox protein engrailed-2 (EN2) is a transcription factor that plays a crucial role in the development of the central nervous system, particularly the cerebellum. EN2 contains a highly conserved homeodomain that allows it to bind to DNA and regulate gene expression during embryonic development. It is essential for proper patterning, foliation, and growth of the cerebellum. Altered expression of EN2 can lead to abnormal cerebellar morphology and foliation. Interestingly, EN2 can also be secreted by cells and taken up by neighboring cells, where it may influence their behavior. Dysregulation of EN2 has been associated with several diseases, including autism spectrum disorder (ASD), where genetic variations in the EN2 gene have been identified as susceptibility factors. Additionally, EN2 is expressed in various cancers, such as prostate, bladder, and breast cancer.