Anti-Human EDA2R Antibody Pair

Product Description: Tumor necrosis factor receptor superfamily member 27 (EDA2R), also known as X-linked ectodysplasin-A2 receptor, is a type III transmembrane protein that plays a critical role in ectodermal development. It specifically binds to the EDA-A2 isoform of ectodysplasin, which is essential for the formation and maintenance of various ectodermal structures, including hair follicles, teeth, and sweat glands. EDA2R activates intracellular signaling pathways, notably the NF-kappaB and JNK pathways, through interactions with adaptor proteins such as TRAF3 and TRAF6. Dysregulation or mutations in the EDA2R gene are associated with X-linked hypohidrotic ectodermal dysplasia, a condition characterized by sparse hair, missing teeth, and reduced sweating due to impaired ectodermal development. Additionally, EDA2R has been implicated in tumorigenesis, as its signaling pathways can influence cell proliferation and apoptosis in various cancers. Protein Function: Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6 [The Uniprot Consortium]