Anti-Human Drebrin Antibody Pair

Product Description: Drebrin 1 (DBN1) is an actin cytoskeleton-organizing protein that plays a crucial role in the formation of cell projections and is particularly significant in neuronal development and function. It is involved in actin polymerization and is required for the proper organization of the actin cytoskeleton, which is essential for cell shape and movement. DBN1 is predominantly expressed in the brain, including regions such as the hippocampal formation, amygdala, basal ganglia, and cerebral cortex. In neurons, DBN1 is thought to regulate synaptic plasticity and the targeting of NMDA receptors. While primarily associated with neural functions, recent studies have also implicated DBN1 in myofibroblast differentiation and the promotion of fibrosis-related genes in the heart and lungs. Protein Function: Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections (PubMed:20215400). Required for actin polymerization at immunological synapses (IS) and for the recruitment of the chemokine receptor CXCR4 to IS (PubMed:20215400). Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines (By similarity). Involved in memory-related synaptic plasticity in the hippocampus (By similarity) [The Uniprot Consortium]