Anti-Human Dopamine beta Hydroxylase Antibody Pair

Product Description: Dopamine beta-hydroxylase (DBH) is a copper-containing enzyme that catalyzes the conversion of dopamine to norepinephrine, playing a vital role in catecholamine biosynthesis. This enzyme, which is approximately 290 kDa and composed of four identical subunits, requires ascorbate as a cofactor for its activity. DBH is primarily expressed in noradrenergic neurons of the central and peripheral nervous systems, as well as in chromaffin cells of the adrenal medulla. Mutations or deficiencies in DBH can lead to dopamine beta-hydroxylase deficiency, a rare disorder characterized by low norepinephrine levels, resulting in symptoms such as orthostatic hypotension and impaired stress response. Additionally, variations in DBH activity have been implicated in psychiatric conditions such as schizophrenia, attention deficit hyperactivity disorder (ADHD), and substance use disorders like alcoholism. Protein Function: Catalyzes the hydroxylation of dopamine to noradrenaline (also known as norepinephrine), and is thus vital for regulation of these neurotransmitters [The Uniprot Consortium]