Anti-Human DOP1B Antibody Pair

Product Description: DOP1 leucine zipper like protein B (DOP1B) is encoded by the DOP1B gene located on human chromosome 21 at band 21q22.12. The protein is large, comprising 2298 amino acids with structural features including an N-terminal domain, seven transmembrane domains, and a C-terminal leucine zipper-like coiled coil domain, suggesting involvement in transcription factor interactions and protein-protein binding. This indicates a potential role as a transcription co-activator. DOP1B is ubiquitously expressed, particularly in differentiating tissues such as the brain, placenta, and erythroleukemia cells, and is localized mainly in the Golgi membrane, trans-Golgi network, cytosol, and extracellular exosomes. Functionally, DOP1B is implicated in cell differentiation, developmental patterning, cognition, and intracellular membrane transport between the Golgi and endosomes. Clinically, DOP1B overexpression (gene triplication) has been linked to Down Syndrome phenotypes, particularly intellectual disability and altered brain cell architecture, paralleling cognitive deficits seen in the condition. Additionally, mutations in DOP1B have been implicated in autosomal recessive Peters anomaly, a developmental eye disorder. Protein Function: May play a role in regulating membrane trafficking of cargo proteins. Together with ATP9A and MON2, regulates SNX3 retromer-mediated endosomal sorting of WLS away from lysosomal degradation [The Uniprot Consortium]