Anti-Human DIAPH3 Antibody Pair

Product Description: Diaphanous related formin 3 (DIAPH3) is a member of the formin homology protein family, primarily functioning as an actin nucleation and elongation factor essential for the assembly of F-actin structures such as actin cables and stress fibers. It plays a critical role in cellular processes including cytokinesis, cell shape changes, adhesion, and division by promoting actin polymerization in both the cytoplasm and nucleus, often in a Rho-dependent manner. DIAPH3 also interacts with microtubules to stabilize their structure and is involved in the regulation of selenoamino acid metabolism through interactions with ribosomal proteins, potentially influencing selenoprotein expression. Disease associations include its implication in auditory neuropathy, autosomal dominant 1 (AUNA1), and its overexpression has been linked to the progression of certain cancers, such as pancreatic cancer, by altering cytoskeletal dynamics and cellular metabolism. Protein Function: Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers. Required for cytokinesis, stress fiber formation and transcriptional activation of the serum response factor. Binds to GTP-bound form of Rho and to profilin: acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity [The Uniprot Consortium]