Anti-Human DECR1 Antibody Pair

Product Description: 2,4-dienoyl-CoA reductase 1 (DECR1) is a protein encoded by the DECR1 gene in humans. It functions as an auxiliary enzyme in the beta-oxidation and metabolism of unsaturated fatty enoyl-CoA esters, specifically those with double bonds in both even- and odd-numbered positions. This enzyme plays a crucial role in lipid metabolism and is involved in the positive regulation of cold-induced thermogenesis. DECR1 has been associated with various diseases, including its role as an androgen-repressed survival factor that protects prostate tumor cells from ferroptosis by regulating PUFA oxidation. Additionally, reduced DECR1 expression has been linked to immune infiltration in cervical cancer, serving as an unfavorable biomarker. Protein Function: Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in mitochondria. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA [The Uniprot Consortium]