Anti-Human DCTN2 Antibody Pair

Product Description: Dynactin subunit 2 (DCTN2), also known as dynamitin, is a critical component of the dynactin complex, which plays an essential role in cellular transport processes, including the movement of organelles and vesicles along microtubules. DCTN2 is involved in various cellular functions such as endocytosis, mitosis, and the positioning of the nucleus. It interacts with cytoplasmic dynein, facilitating the transport of cellular cargoes. Dysregulation of DCTN2 has been linked to several diseases, particularly in cancer, where it has been shown to promote tumor progression. Elevated levels of DCTN2 expression are associated with poor prognosis in various malignancies, including hepatocellular carcinoma (HCC), where it enhances cell proliferation and metastasis by modulating key signaling pathways, such as the AKT pathway. Protein Function: Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length (By similarity). Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (By similarity) [The Uniprot Consortium]