Anti-Human CST6 Antibody Pair

Product Description: Cystatin E/M (CST6) is a cysteine protease inhibitor belonging to the type 2 cystatin family, known for its role in regulating proteolytic activity in various human fluids and tissues. It is encoded by the CST6 gene located on chromosome 11 and is synthesized as a secretory protein with a signal peptide for secretion. CST6 exhibits high affinity for cathepsin L and legumain, playing crucial roles in epidermal cornification and hair follicle maintenance. Loss of CST6 expression has been linked to several diseases, including ectodermal dysplasia and ichthyosis, highlighting its importance in skin and hair development. Furthermore, CST6 is implicated in suppressing osteolytic bone disease in multiple myeloma by inhibiting osteoclast differentiation, underscoring its multifaceted role in disease progression and tissue homeostasis. Overall, CST6 is a significant protein with protective functions that may influence cancer metastasis and other pathological conditions. Protein Function: High affinity inhibitor for cathepsin L, cathepsin L2 (cathepsin V), and legumain (PubMed:30425301). Involved in the regulation of epidermal cornification, and hair follicle morphogenesis and maintenance (PubMed:30425301) [The Uniprot Consortium]