Anti-Human CORO1C Antibody Pair

Product Description: Coronin 1C (CORO1C) is an actin-binding protein belonging to the WD repeat protein family, characterized by multiple WD repeat domains that facilitate the formation of multiprotein complexes and are involved in essential cellular processes such as cytoskeletal organization, cell cycle progression, signal transduction, and apoptosis. CORO1C plays a specialized role in regulating branched actin structures, particularly at endosomal membranes, where it confines actin to specific regions to control endosome fission and receptor sorting, thereby influencing cell shape, adhesion, and intracellular trafficking. In terms of disease association, CORO1C is frequently upregulated in several cancers, including colorectal, hepatocellular, and gastric cancers, where its overexpression correlates with increased tumor invasiveness, metastasis, and poor patient prognosis, highlighting its potential as a biomarker for aggressive cancer phenotypes. Protein Function: Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1 (PubMed:25074804, PubMed:25925950). Increases the presence of activated RAC1 at the leading edge of migrating cells (PubMed:25074804, PubMed:25925950). Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments (By similarity). Plays a role in endoplasmic reticulum-associated endosome fission: localizes to endosome membrane tubules and promotes recruitment of TMCC1, leading to recruitment of the endoplasmic reticulum to endosome tubules for fission (PubMed:30220460). Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane (PubMed:30220460). Required for normal cell proliferation, cell migration, and normal formation of lamellipodia (By similarity). Required for normal distribution of mitochondria within cells (By similarity) , Involved in myogenic differentiation [The Uniprot Consortium]