Anti-Human CHRDL2 Antibody Pair

Product Description: Chordin-like 2 (CHRDL2) is a protein encoded by the CHRDL2 gene located on chromosome 11 in humans. This protein plays a crucial role in various biological processes, particularly in cell proliferation and tumorigenesis. It has been implicated in promoting the proliferation of gastric cancer cells by activating the YAP/TAZ signaling pathway, which is essential for cellular growth and survival. Additionally, CHRDL2 acts as an inhibitor of bone morphogenetic proteins (BMPs), potentially affecting their interaction with receptors and thereby influencing developmental processes and disease mechanisms. Dysregulation of CHRDL2 has been associated with several cancers, including osteosarcoma, where it promotes not only cell proliferation but also metastasis. Overall, CHRDL2 is emerging as a significant player in cancer biology, highlighting its potential as a therapeutic target. Protein Function: May inhibit BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation (By similarity). Implicated in tumor angiogenesis. May play a role during myoblast and osteoblast differentiation, and maturation [The Uniprot Consortium]