Anti-Human CHRDL1 Antibody Pair

Product Description: Chordin-like 1 (CHRDL1) is a secreted glycoprotein that functions primarily as an antagonist of bone morphogenetic proteins (BMPs), particularly BMP-4. It plays crucial roles in various biological processes, including osteogenesis, neurogenesis, and tumor suppression. CHRDL1 is involved in the differentiation of osteoblasts and adipocytes, with studies indicating that it promotes adipogenesis while suppressing osteogenic differentiation through modulation of signaling pathways, including AKT/mTORC1 and interactions with insulin-like growth factor binding protein 3 (IGFBP3). Dysregulation of CHRDL1 has been linked to several diseases, notably non-syndromic X-linked megalocornea due to mutations affecting its function, and various cancers where it may act as a tumor suppressor or promoter depending on the context. Protein Function: Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation (By similarity). May also play an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Plays a role during anterior segment eye development [The Uniprot Consortium]