Anti-Human CD6 Antibody Pair

Product Description: T-cell differentiation antigen CD6 (CD6) is a type I transmembrane glycoprotein primarily expressed on T lymphocytes, playing a crucial role in immune responses. CD6 interacts with its ligand, CD166, enhancing T-cell activation and promoting cell survival. This interaction is essential for the formation of a signaling complex that modulates T-cell responses, making CD6 a potential co-stimulatory receptor. However, its role can be context-dependent, exhibiting both co-stimulatory and inhibitory functions based on the cellular environment and the specific immune context. Dysregulation of CD6 has been implicated in various autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, where it may contribute to the pathogenesis by affecting T-cell activation and differentiation. In these conditions, altered CD6 expression can lead to excessive T-cell activation, promoting inflammation and tissue damage. Protein Function: Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166 (PubMed:15048703, PubMed:15294938, PubMed:16352806, PubMed:16914752, PubMed:24584089, PubMed:24945728). Contributes to signaling cascades triggered by activation of the TCR/CD3 complex (PubMed:24584089). Functions as a costimulatory molecule, promotes T-cell activation and proliferation (PubMed:15294938, PubMed:16352806, PubMed:16914752). Contributes to the formation and maturation of the immunological synapse (PubMed:15294938, PubMed:16352806). Functions as a calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria (PubMed:17601777). LPS binding leads to the activation of signaling cascades and down-stream MAP kinases (PubMed:17601777). Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS (PubMed:17601777) [The Uniprot Consortium]