Anti-Human Carcino Embryonic Antigen CEA (CD66e) Antibody Pair

Product Description: CEACAM5, also known as carcinoembryonic antigen (CEA), is a member of the CEACAM family of glycoproteins, characterized by its glycosylphosphatidylinositol (GPI) anchor and multiple immunoglobulin-like domains. This protein plays a crucial role in cell adhesion and is primarily expressed in the gastrointestinal tract, particularly in the colon. Its expression is significantly upregulated in various cancers, making it a valuable diagnostic and prognostic marker for colorectal cancer. CEACAM5 is involved in several physiological processes, including immune modulation and differentiation, and its dysregulation is associated with tumorigenesis and the progression of gastrointestinal diseases. Additionally, it serves as a receptor for certain pathogens, highlighting its importance in both health and disease contexts. Protein Function: Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:10864933, PubMed:10910050, PubMed:2803308). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:2803308). Plays a role as an oncogene by promoting tumor progression, induces resistance to anoikis of colorectal carcinoma cells (PubMed:10910050) , (Microbial infection) Receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer [The Uniprot Consortium]