Anti-Human ARAP3 Antibody Pair

Product Description: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 (ARAP3) is a protein that plays a crucial role in modulating actin cytoskeleton remodeling by regulating ARF and RHO family GTPases. It is a phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that is implicated in phosphoinositide 3-kinase (PI 3-kinase) signaling pathways. The protein contains multiple domains including ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin homology domains, which enable it to interact with various signaling molecules. ARAP3 is expressed in various tissues, including the brain, thyroid gland, lung, and others, indicating its widespread involvement in cellular processes. Its role in PI 3-kinase signaling pathways suggests potential implications in diseases related to cell signaling and cytoskeleton regulation. Protein Function: Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin [The Uniprot Consortium]