Anti-Human ADK Antibody Pair

Product Description: Adenosine kinase (ADK) is a cytoplasmic and nuclear enzyme critical for adenosine homeostasis, catalyzing the phosphorylation of adenosine to adenosine monophosphate (AMP) using ATP. This reaction regulates extracellular adenosine levels, influencing purine metabolism, DNA methylation, and adenosine receptor signaling. ADK exists in two isoforms: ADK-long (ADK-L), predominantly nuclear and associated with transcriptional regulation, and ADK-short (ADK-S), cytoplasmic and involved in metabolic clearance of adenosine. The enzyme's activity is pivotal in maintaining cellular energy balance and modulating neuroprotective, anti-inflammatory, and anticonvulsant adenosine-mediated pathways. ADK dysfunction is linked to hypermethioninemia, a metabolic disorder characterized by elevated methionine due to impaired S-adenosylhomocysteine hydrolysis. Additionally, ADK overexpression in epilepsy reduces adenosine's anticonvulsant effects. ADK deficiency may also contribute to liver disease and developmental abnormalities. Protein Function: Catalyzes the phosphorylation of the purine nucleoside adenosine at the 5' position in an ATP-dependent manner. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides [The Uniprot Consortium]