Anti-Human ADAMTS15 Antibody Pair

Product Description: ADAM metallopeptidase with thrombospondin type 1 motif 15 (ADAMTS15) is a member of the ADAMTS family, which consists of 19 secreted zinc metalloproteases. It is involved in various biological processes, including modulation of cell-extracellular matrix interactions, which are crucial in tumor pathophysiology. The protein exhibits proteolytic activity against the proteoglycan VCAN. ADAMTS15 is expressed in multiple tissues, including cytoplasmic expression in most tissues and additional luminal membrane expression in the gastrointestinal tract. It has been identified as a candidate gene for intracranial aneurysms, suggesting a potential role in vascular diseases. Overall, ADAMTS15 plays a significant role in extracellular matrix remodeling and may contribute to various pathological conditions. Protein Function: Metalloprotease which has proteolytic activity against the proteoglycan VCAN, cleaving it at the 'Glu-1428-, -1429-Ala' site. Cleaves VCAN in the pericellular matrix surrounding myoblasts, facilitating myoblast contact and fusion which is required for skeletal muscle development and regeneration [The Uniprot Consortium]