Products from NewEast Biosciences
NewEast Biosciences, headquartered in King of Prussia, Pennsylvania, produces antibodies, proteins and assay kits with a strong focus on G-protein research. You also find mutation-specific antibodies as well as cAMP and cGMP kits with extraordinary specificity due to the use of monoclonal antibodies.
More information at: www.neweastbio.com
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Anti-Ras (A146P)
Item number: NB-26478
Concentration: 1 mg/ml. Formulation: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol. Protein function: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation (PubMed:23698361, PubMed:22711838). Plays a role in promoting...
| Keywords: | Anti-KRAS, Anti-KRAS2, mutation-specific (Ala146Pro) |
| Application: | ELISA, IHC, IF |
| Host: | Mouse |
| Species reactivity: | vertebrates |
746.00€
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Anti-EGFR (T854A)
Item number: NB-26481
Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol. EGFR is a receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. It activates at least 4 major downstream signaling cascades...
| Keywords: | Anti-EGFR, Anti-ERBB, EC=2.7.10.1, Anti-Proto-oncogene c-ErbB-1, Anti-Epidermal growth factor receptor, Anti-Receptor... |
| Application: | ELISA, WB, IF, IHC |
| Host: | Mouse |
| Species reactivity: | vertebrates |
746.00€
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Anti-EGFR (S768I)
Item number: NB-26483
Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol. EGFR is a receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. It activates at least 4 major downstream signaling cascades...
| Keywords: | Anti-EGFR, Anti-ERBB, EC=2.7.10.1, Anti-Proto-oncogene c-ErbB-1, Anti-Epidermal growth factor receptor, Anti-Receptor... |
| Application: | ELISA, WB, IF, IHC |
| Host: | Mouse |
| Species reactivity: | vertebrates |
746.00€
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Anti-Active G.alpha.z, monoclonal
Item number: NB-26908
Concentration: 1 mg/ml. Formulation: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol. Heterotrimeric G proteins are critical cellular signal transducers. Gaz represents one sub-family of G proteins that could mediate the inhibition of adenylyl cyclases. Other biochemical and physiological functions of...
| Keywords: | Anti-GNAZ, Anti-Gz-alpha, Anti-G(x) alpha chain, Anti-Guanine nucleotide-binding protein G(z) subunit alpha |
| Application: | IP, IHC |
| Host: | Mouse |
| Species reactivity: | vertebrates |
746.00€
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Anti-active Arl3, monoclonal
Item number: NB-26925
Concentration: 1 mg/ml. Formulation: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol. Arl3 (Arf-like 3) is an Arf family protein. Arl3 binds microtubules to alter specific aspects of cytokinesis. It has been proposed that retinitis pigmentosa 2 functions in concert with Arl3 to link the cell membrane...
| Keywords: | Anti-ARL3, Anti-ARFL3, Anti-ADP-ribosylation factor-like protein 3 |
| Application: | IP, IHC, IF |
| Host: | Mouse |
| Species reactivity: | vertebrates |
746.00€
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Cdc42 G12V mutant (Cell division cycle 42, G25K,...
Item number: NB-10109
Small GTPases are a super-family of cellular signaling regulators. Cdc42 belongs to the Rho sub-family of GTPases that regulate cell motility, cell division, and gene transcription. GTP binding increases the activity of Cdc42, and the hydrolysis of GTP to GDP renders it inactive. GTP hydrolysis is aided by GTPase...
| Keywords: | CDC42, G25K GTP-binding protein, Cell division control protein 42 homolog |
| Expressed in: | E.coli |
| Origin: | human |
| MW: | 21 kD |
397.00€
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Ran Q69L mutant (Ras-related nuclear protein, TC4, Gsp1,...
Item number: NB-10113
Ran is a member of the Ras-superfamily GTPases. Ran is invovled in control of DNA synthesis and of cell cycle progression, and the transport of proteins across the nuclear envelope, as well as in microtubule organization during mitosis.
| Keywords: | RAN, ARA24, GTPase Ran, Ras-like protein TC4, Ras-related nuclear protein, GTP-binding nuclear protein Ran, Androgen... |
| Expressed in: | E.coli |
| Origin: | human |
| MW: | 24 kD |
384.00€
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Rab5 Q79L mutant (Member RAS oncogene family, RAB5A),...
Item number: NB-10117
Rab5, consists of three isoforms, Rab5A, Rab5B, and Rab5C, is a small GTPase that is localized to early endosomes. It regulates the fusion between endocytic vesicles and early endosomes, as well as the homotypic fusion between early endosomes.
| Keywords: | RAB5, RAB5A, Ras-related protein Rab-5A |
| Expressed in: | E.coli |
| Origin: | human |
| MW: | 17 kD |
384.00€
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![Arf1 delta17 Q71L mutant (ADP-ribosylation factor 1), human recombinant, His6-tag [E. coli]](https://www.biomol.com/media/image/0c/96/5c/NB-10123_200x200.jpg "Arf1 delta17 Q71L mutant (ADP-ribosylation factor 1), human recombinant, His6-tag [E. coli]")
Arf1 delta17 Q71L mutant (ADP-ribosylation factor 1),...
Item number: NB-10123
Arf1 is a member of the ARF super-family. ARF genes encode small GTPases that increase the ADP-ribosyltransferase activity of cholera toxin and are critical for vesicular trafficking as activators of phospholipase D. Arf1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport.
| Keywords: | ARF1, ADP-ribosylation factor 1 |
| Expressed in: | E.coli |
| Origin: | human |
| MW: | 21 kD |
540.00€
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![Rab3A Q81L mutant (Member RAS oncogene family), human, recombinant full length, His6-tag [E. coli]](https://www.biomol.com/media/image/b5/fc/1f/NB-10129_200x200.jpg "Rab3A Q81L mutant (Member RAS oncogene family), human, recombinant full length, His6-tag [E. coli]")
Rab3A Q81L mutant (Member RAS oncogene family), human,...
Item number: NB-10129
The Rab3 small G protein family consists of four members, Rab3A, -3B, -3C, and -3D. Rab3A is found specifically in brain and regulates a late step in synaptic vesicle fusion. Rab3A -mediated synaptic transmission is involved in circadian period and sleep homeostasis.
| Keywords: | RAB3A, Ras-related protein Rab-3A |
| Expressed in: | E.coli |
| Origin: | human |
| MW: | 25 kD |
540.00€
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Rab4A Q67L mutant (Member RAS oncogene family, RAB4,...
Item number: NB-10131
The Rab family of Ras-related GTP-binding protein Rab4 is involved in bidirectional sarcolemmal-vesicular Adrb2 trafficking, which occurs continuously in healthy hearts and is necessary for normal baseline adrenergic responsiveness and resensitization after catecholamine exposure.
| Keywords: | RAB4, RAB4A, Ras-related protein Rab-4A |
| Expressed in: | E.coli |
| Origin: | human |
| MW: | 24 kD |
397.00€
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Rab7 Q67L mutant (Member RAS oncogene family, Rab7a,...
Item number: NB-10135
Members of the Rab family of Ras-related GTP-binding proteins are important regulators of vesicular transport and are located in specific intracellular compartments. Rab7 has been localized to late endosomes and shown to be important in the late endocytic pathway. In addition, it has been shown to have a fundamental...
| Keywords: | RAB7, RAB7A, Ras-related protein Rab-7a |
| Expressed in: | E.coli |
| Origin: | human |
| MW: | 23 kD |
397.00€
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