Products from MONOSAN

MON1082 recognizes common epitope on human HLA-DR, which is dependent on the association of the alpha and beta chains. Recognized epitope is conserved after fixation with glutaraldehyde and formaldehyde. HLA-DR, a member of MHC class II glycoproteins, that bind intracellularly processed peptides and present them to...

MON1083 reacts with common epitope on beta-chain of human HLA-DR and HLA-DP. DR and DP are the isotypes of human MHC Class II molecules expressed on antigen-presenting cells (APC, dendritic cells, B lymphocytes, monocytes, macrophages).

MON1084 reacts with polymorphic determinant on human HLA-DQ1 andHLA-DQ3 molecules (recognized epitope was found on isolated beta chain of DQ1), but does not react with HLA-DQ2. DQ is the isotype of human MHC Class II molecules expressed on antigen-presenting cells (APC, dendritic cells, B lymphocytes, monocytes,...

MON1085 reacts with CD48 antigen (Blast-1), a 40-47 kDa GPI-anchored membrane protein (immunoglobulin supergene family) widely expressed on hematopoietic cells. CD48 is a GPI-anchored protein broadly expressed on hematopoietic cells and serves as a high affinity ligand for 2B4 and low affinity ligand for CD2....

MON1100 reacts with a 59 kD glycoprotein specific for the CD4 antigen, which functions as a receptor for MHC class II and for HIV. The antigen is characteristic for helper T-cells. The specificity was confirmed by testing with CD4 cDNA transfected cells, with purified CD4 antigen and competition studies with other...

MON1102 recognizes a conformationally-dependent epitope of CD8, a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 T cell coreceptor (monomer approx. 32-34 kDa) is expressed as alpha/beta heterodimer on majority of MHC...

MON1102 recognizes a conformationally-dependent epitope of CD8, a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 T cell coreceptor (monomer approx. 32-34 kDa) is expressed as alpha/beta heterodimer on majority of MHC...

MON1103 reacts with CD10 antigen (CALLA - Common acutelymphatic leukemia antigen), a 100 kDa type II integral membrane protein. CD10 is expressed on various normal cell types, including lymphoid precursor cells, germinal center B lymhocytes, and some epithelial cells, and its expression level serves as a marker for...

MON1104 reacts with CD11a (alpha subunit of human LFA-1), a 170-180 kDa type I transmembrane glycoprotein expressed on B and T lymphocytes, monocytes, macrophages, neutrophils, basophils and eosinophils. Cell stimulation by chemokines or other signals leads to induction the high-affinity conformation, which supports...

MON1107 recognizes CD17, a membrane lipid moiety lactosylceramide expressed on granulocytes, monocytes and platelets. Besides playing a pivotal role in the biosynthesis of complex glycosphingilipids, lactosylceramide is involved in cell-cell and cell-matrix interactions and in signaling events linked to cell...

MON1108 recognizes CD14, a 55 kDa GPI-anchored glycoprotein, which is constitutively expressed on the surface of mature monocytes, macrophages, and neutrophils, where serves as a multifunctional lipopolysaccharide receptor, it is also released to the serum both as a secreted and enzymatically cleaved GPI-anchored...

CD18 integrin beta 2 subunit is a 90 kDa type I transmembrane protein expressed on all leucocytes. CD18 can combine with integrin molecules CD11a-c to form heterodimers at the cell surface, and these heterodimers are known to participate in the process of cell adhesion as well as cell-surface mediated signaling....