Products from MONOSAN

MON1067 reacts with CD22, a 130 kDa type Itransmembrane glycoprotein (immunoglobulin superfamily) expressed in the cytoplasm of pro-B and pre-B lymphocytes, and on the surface of mature and activated B lymphocytes. Intracellular domain of CD22 recruits protein tyrosine phosphatase SHP1 through the immunoreceptor...

MON1068 recognizes an epitope in the D2 domain of CD50 (ICAM-3), a 120-130 kDa type I membrane protein (immunoglobulin supergene family) expressed on leukocytes, endothelial cells and Langerhans cells. CD50 is a transmembrane glycoprotein expressed by leukocytes, that serves as a counterreceptor for the lymphocyte...

MON1070 reacts with CD98, a 125 kDa disulfide-linked heterodimer (80 kDa glycosylated heavy chain + 45 kDa non-glykosylated light chain). CD98 is expressed on T lymphocytes (upon activation) and activated NK cells, it is also present at low levels on B lymphocytes, NK cells, monocytes and platelets. CD98 (4F2) is a...

MON1070 recognizes an epitope in the N-terminal Ig domain (D1) of CD147 (Neurothelin), a 50-60 kDa type I transmembrane glycoprotein primarily expressed on all leukocytes, red blood cells, platelets and endothelial cells, it is not expressed by resting lymphocytes. CD147 (basigin, neurothelin, OX-47, 5A11, CE9, M6)...

MON1070 reacts with CD14, a 53-55 kDa GPI (glycosylphosphatidylinositol)-linked membrane glycoprotein expressed on monocytes, macrophages and weakly on granulocytes, also expressed by most tissue macrophages. CD14 binds lipopolysaccharide molecule in a reaction catalyzed by lipopolysaccharide-binding protein (LBP),...

CDw78 (also called Ba antigen, Leu21 or LO panB a) is present on some immature and some mature Bcells. The antigen appears on B-cell progenitors preceding CD10, CD19, CD22, and CD37. It is expressed on resting B-cells and reappears and persists in the cytoplasm and on the cell surface until cytoplasmic Ig appears....

MON1075 reacts with CD29 (integrin beta1 chain), a 130 kDa single chain type I glycoprotein expressed as a heterodimer (non-covalently associated with the integrin alpha subunits 1-6). CD29 (beta1 integrin subunit, GPIIa) forms non-covalently linked heterodimers with at least 6 different alpha chains (alpha1-...

MON1076 reacts with human CD81 (TAPA-1), a 24 kDa member of the TM4 superfamily of proteins with four transmembrane domains. MAbs to CD81 have been shown to have anti-proliferative effects on different lymphoid cell lines, particularly those derived from large cell lymphomas. CD81 can associate with CD37 and/or...

MON1077 reacts with human CD84 (Mw 74 kDa). CD84 is expressed on mature B-cells and on Bcell lines but not on plasma cell lines. Immunohistochemistry demonstrated that it strongly stains tissue macrophages. It is also expressed on platelets and at low levels on blood T-cells. It is a highly N-glycosylated protein...

MON1078 is specific for CD29, an adhesion receptor and costimulatory molecule. This antigen was initially characterized as gpIIa on platelets and as the common beta1 subunit of the very late antigen (VLA) protein family. CD29 forms a non-covalent heterodimeric complex with integrin alpha subunits. It is also...

MON1078 is specific for CD28, a glycoprotein of 44-88 kDa, is the critical T-cell co-stimulatory receptor which provides to the cell the important second activation signal by binding CD80 and CD86 that are expressed by antigen presenting cells. Protein function: Involved in T-cell activation, the induction of cell...

MON1081 reacts with human leukocyte antigen-DR (HLA-DR). The mAb has lymph node germinal center and mantle zone B cell reactivity. It reacts with interdigitating histiocytes in T cell zones and with sinus histiocytes and endothelial cells. It has also tumor specificity and reactivity with normal nonlymphoid tissue....