Products from MONOSAN

MON1023 specifically reacts with CD1a, an MHC like transmembrane glycoprotein of 49 kDa, that presents lipid molecules and is non-covalently associated with beta2-microglobulin. The antigen is strongly expressed on cortical thymocytes and dendritic cells and disappears at later stages of maturation. Protein...

MON1025 reacts with CD11a, a transmembrane molecule with 1145 amino acid residues and a MW of 180 kDa. CD11a is expressed on lymphocytes, granulocytes, monocytes and macrophages. Levels on memory T-cells tend to increase. CD11a plays a key role in mediating leukocyte adhesion to endothelium during inflammatory...

MON1027 reacts with CD15 (220 kDa). CD15 is present on >95% of granulocytes including neutrophils and eosinophils and to a lesser degree on monocytes. CD15 is further expressed in Reed-Sternberg cells in classic Hodgkin's disease. CD15 is occasionally expressed in large cell lymphomas of both B and T phenotypes. It...

MON1029 reacts with Human CD16. Mab MEM-154 reacts with epitope residing in proximity to FG loop (probably BC or C'E loop). Mab recognizes a polymorphism of CD16a (NK cells form) and reacts well with granulocyte form (CD16b) of all subjects. Protein function: Receptor for the Fc region of immunoglobulins gamma. Low...

MON1030 reacts with human CD26 (Dipeptidyl peptidase IV), a 110 kDa protein which occurs in the cell membrane of T-lymphocyte and is upregulated after activation. CD26 is also present on endothelial cells and also expressed on activated B-cells and natural killer cells and abundantly on epithelia. CD26 is implicated...

MON 1031A reacts with beta2-microglobulin (beta2M) associated with cell-surface MHC Class I molecules and other membrane antigens as well as with soluble beta2-microglobulin. Beta2M is a 12 kDa Ig like glycoprotein expressed on lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells and...

MON1033 reacts with a protein determinant of the extra cellular domain of the human EGFR, and does not cross react with EGFR from murine cells. The antibody shows binding competition with EGF. The antibody reacts in immunoprecipitation with the functional EFR protein-tyrosine kinase complex. Protein function:...

MON1034 recognizes a 150/130 kD receptor for fibronectin, (VLA-alpha-5 protein from the integrin superfamily of antigens). The antibody reacts with platelets, lymphocytes, monocytes and most cell lines including K562 and U937. Protein function: Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and...

MON1035 reacts with CD37, a B lineage restricted antigen, strongly expressed throughout B-cell ontogeny from pre B-cell until plasmablasts. Plasma cells are negative. IPO-24 reacts with human B-cell lines Daudi, Raji, Namalva, Ramos and CABIL, whereas T-cell lines CEM, Molt-4, Jurkat, MT-4, H9 and non-lymphoid cell...

MON1042F reacts with CD22, a type 1 integral membrane glycoprotein with molecular weight of 130 to 140 kDa. CD22 is expressed in both the cytoplasm and cell membrane of B-lymphocytes. CD22 antigen appears early in B-cell lymphocyte differentiation at approximately the same stage as the CD19 antigen. Unlike other...

MON1042R reacts with CD22, a type 1 integral membrane glycoprotein with molecular weight of 130 to 140 kDa. CD22 is expressed in both the cytoplasm and cell membrane of B-lymphocytes. CD22 antigen appears early in B-cell lymphocyte differentiation at approximately the same stage as the CD19 antigen. Unlike other...

MON1043F reacts with CD23, a 45 kDa glycoprotein which is present on a subpopulation of freshly isolated peripheral blood and tonsil B cells and strongly expressed on EBV-transformed B lymphoblasts. The CD23 molecule is identical to the low affinity IgE receptor found on B cells. Expression of CD23 has been detected...