Products from MONOSAN

MON4000 recognizes mouse nectin-3. Nectin-3 is a 83 kDa type I transmembrane glycoprotein. Nectin, originally isolated as poliovirus receptor-related protein (PRR), is a cell-cell adhesion molecule of the immunoglobulin supergene family. Nectins are calcium independent immunoglobulin-like cell-cell adhesion...

Protein function: May be an organic anion pump relevant to cellular detoxification. [The UniProt Consortium]

MON9806 reacts with mouse Mrp6, a 165 kD transmembrane protein that is related to the multidrug resistance related protein Mrp1. Mutations in the human MRP6 gene are responsible for the connective tissue disorder Pseudoxanthoma elasticum (PXE). M6II-24 was raised against a bacterial fusion protein of mouse Mrp6,...

Intended use: Monosan(R) Permanent AP Red Kit is developed for immunohistochemical and in situ-hybridisation staining procedures with alkaline phosphatase. Monosan(R) Permanent AP Red leads to the formation of a magenta-red precipitate at the location of the target antigen or target nucleic acid. The precipitate is...

Protein function: Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by...

The human progesterone receptor (PR) is expressed as two isoforms, PRA (94 kD) and PRB (114 kD), which function as ligand-activated transcription factors. These two isoforms are transcribed from distinct estrogen receptor (ER)-inducible promoters within a single copy PR gene. MONX10121 is recommended for determining...

The CD4 molecule (T4) is a single chain transmembrane glycoprotein with a molecular weight of 59 kD. The CD4 antigen is expressed on a T cell subset (helper/inducer) representing 45 percent of peripheral blood lymphocytes and at a lower level on monocytes. Most cases of cutaneous T cell lymphoma, including mycosis...

MONX11130 is recommended for the detection of CD123 in normal and neoplastic tissues, particularly to aid in the identification of plasmacytoid dendritic cell neoplasms. Protein function: This is a receptor for interleukin-3. [The UniProt Consortium] Protein function: This is a receptor for interleukin-3. [The...

Anti-Lysozyme stains myeloid cells, histiocytes, granulocytes, macrophages, and monocytes in human tonsil, colon and skin. It is an important marker that may demonstrate the myeloid or monocytic nature of acute leukemia. The restrictive nature of anti-lysozyme antibody staining suggests that lysozyme may be...

UACA (Uveal Autoantigen with Coiled-coil domains and Ankyrin repeats) is a 1,416 amino acid nuclear membrane protein. It was originally identified as an autoantigen in patients with panuveitis, a characteristic of Vogt-Koyanagi-Harada disease, and in patients with Graves' disease. UACA was also later identified as...

MON1019 is an alpha chain integrin that is expressed as heterodimer non-covalently associated with CD18. CD11b is also designated as CR3, Mac-1, Mo-1 in integrin alphaM subunit and has a molecular weight of 165-170 kDa. The protein mediates PMN and monocytes adherence to endothelium and subsequently PMN...

CD11b (integrin alpha-M, ITGAM, integrin alpha-X, ITGAX) is a 165 kDa adhesion molecule that associates non-covalently with integrin beta-2 (CD18). The CD11b/CD18 heterodimeric complex is also known as integrin alpha-M beta-2, Mac-1, and CR3 (complement receptor 3). CD11b is expressed on the surface of...