Products from GenScript
GenScript Biotech Corporation is a leading global provider of research products supporting life science innovation. Their extensive portfolio includes custom genes, peptides, proteins, antibodies, and oligonucleotides, along with a wide range of CRISPR tools, cloning vectors, expression systems, and cell culture reagents. With high-quality standards and reliable delivery, GenScript enables researchers worldwide to accelerate discoveries across molecular biology, immunology, and drug development.
More information at: www.genscript.com
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ALCAM/CD166, His, Cynomolgus
Item number: GSC-Z04727-100
Brain metastasis (BM) in non-small-cell lung cancer (NSCLC) has a very poor prognosis. Recent studies have demonstrated the importance of cell adhesion molecules in tumor metastasis.Elevated levels of ALCAM expression promote BM formation in NSCLC through increased tumor cell dissemination and interaction with the...
| Keywords: | ALCAM, CD166 antigen, Activated leukocyte cell adhesion molecule |
| Origin: | cynomolgus |
| MW: | 57.1 kD |
From 524.00€
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ALK-1/ACVRL1, His, Cynomolgus
Item number: GSC-Z04728-100
Activin receptor-like kinase 1 (ALK1)-mediated endothelial cell signalling in response to bone morphogenetic protein 9 (BMP9) and BMP10 is of significant importance in cardiovascular disease and cancer. Structural analyses reveal a tripartite recognition mechanism that defines BMP9 and BMP10 specificity for ALK1,...
| Keywords: | ACVRL1, Serine/threonine-protein kinase receptor |
| Origin: | cynomolgus |
| MW: | 11.86 kD |
From 524.00€
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AMIGO2, His, Cynomolgus
Item number: GSC-Z04730-100
Bromodomain and extraterminal domain inhibitors (BETi) represent promising therapeutic agents for metastatic melanoma, yet their mechanism of action remains unclear. Here we interrogated the transcriptional effects of BETi and identified AMIGO2, a transmembrane molecule, as a BET target gene essential for melanoma...
| Keywords: | AMIGO2, AMIGO-2, Amphoterin-induced protein 2 |
| Origin: | cynomolgus |
| MW: | 41.97 kD |
From 524.00€
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B7-2/CD86, His, Cynomolgus
Item number: GSC-Z04740-100
B7-1 and B7-2 are homologous costimulatory ligands expressed on the surface of antigen presenting cells (APCs). Binding of these molecules to the T cell costimulatory receptors, CD28 and CTLA-4, is essential for the activation and regulation of T cell immunity. B7-1 and B7-2 do not form hetero-oligomers,...
| Keywords: | Activation B7-2 antigen, T-lymphocyte activation antigen CD86 |
| Origin: | cynomolgus |
| MW: | 26.4 kD |
From 457.00€
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BDCA-2 mFc Chimera, Cynomolgus
Item number: GSC-Z04747-100
BDCA-2, BDCA-3, and BDCA-4. In blood, BDCA-2 and BDCA-4 are expressed on CD11c(-) CD123(bright) plasmacytoid dendritic cells, whereas BDCA-3 is expressed on small population of CD11c() CD123(-) dendritic cells. All three Ags are not detectable on a third blood dendritic cell population, which is CD1c() CD11c(bright)...
| Keywords: | CLEC4C |
| Origin: | cynomolgus |
| MW: | 46 kD |
From 524.00€
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BST1, His, Cynomolgus
Item number: GSC-Z04751-100
BST1 overexpression conferred resistance to sphingosine in yeast. BST1 deletion produced sensitivity to exogenous D-erythro-sphingosine and phytosphingosine and intracellular accumulation of sphingosine 1-phosphate upon exposure to exogenous sphingosine. sphingoid base metabolism is similar in all eukaryotes and...
| Keywords: | BST1, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase |
| Origin: | cynomolgus |
| MW: | 30.99 kD |
From 524.00€
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BST2, His, Cynomolgus
Item number: GSC-Z04752-100
Interferon-induced BST2 (bone marrow stromal cell antigen 2) inhibits viral replication by tethering enveloped virions to the cell surface to restrict viral release and by inducing the NFKB-dependent antiviral immune response. BST2 expression was significantly increased during porcine epidemic diarrhea virus (PEDV)...
| Keywords: | Bone marrow stromal antigen 2 |
| Origin: | cynomolgus |
| MW: | 13.78 kD |
From 524.00€
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CD10/MME, His, Cynomolgus
Item number: GSC-Z04760-100
CD10 is an endopeptidase that degrades various bioactive peptides in the extracellular matrix. In addition to enzymatic degradation, it affects multiple intracellular signal transduction pathways. CD10 expression has been extensively studied in human epithelial cancers of numerous organs and sites. CD10 expression...
| Keywords: | MME, Neprilysin, Enkephalinase, Atriopeptidase, Skin fibroblast elastase, Neutral endopeptidase 24.11 |
| Origin: | cynomolgus |
| MW: | 80.69 kD |
From 524.00€
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CTLA-4/CD152, His, Cynomolgus
Item number: GSC-Z04773-100
CTLA-4 (cytotoxic T-lymphocyte-associated protein 4), also known as CD152, is a protein receptor that, functioning as an immune checkpoint, downregulates immune responses.CTLA4 is constitutively expressed in regulatory T cells but only upregulated in conventional T cells after activation - a phenomenon which is...
| Keywords: | CTLA4, Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4 |
| Origin: | cynomolgus |
| MW: | 14.4 kD |
From 188.00€
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CX3CL1/Fractalkine, His, Cynomolgus
Item number: GSC-Z04774-100
Fractalkine/CX3C chemokine ligand 1 (CX3CL1) is a chemokine involved in the anticancer function of lymphocytes-mainly NK cells, T cells and dendritic cells. Its increased levels in tumors improve the prognosis for cancer patients, although it is also associated with a poorer prognosis in some types of cancers, such...
| Keywords: | CX3CL1 |
| Origin: | cynomolgus |
| MW: | 34.65 kD |
From 524.00€
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CXCL10, His, Cynomolgus
Item number: GSC-Z04775-100
C-X-C motif ligand 10 (CXCL10), or interferon-inducible protein-10, is a small chemokine belonging to the CXC chemokine family. Its members are responsible for leukocyte trafficking and act on tissue cells, like endothelial and vascular smooth muscle cells. CXCL10 is secreted by leukocytes and tissue cells and...
| Keywords: | CXCL10, C-X-C motif chemokine |
| Origin: | cynomolgus |
| MW: | 8.36 kD |
From 524.00€
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EPHA2, His & Avi, Cynomolgus
Item number: GSC-Z04783-100
Ephrin type-A receptor 2 (EPHA2) is a receptor tyrosine kinase (RTK), whose over-expression has been observed in a variety of cancers, including breast cancer. EPHA2 expression may be causally related to tumorigenesis, therefore, it is important to understand how EPHA2 gene (EPHA2) expression is regulated.
| Keywords: | EPHA2, Ephrin type-A receptor 2 |
| Origin: | cynomolgus |
| MW: | 59.2 kD |
From 524.00€
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