Irisin (human, recombinant)

Physical exertion and exercise are the primary defenses against obesity, insulin resistance, and diabetes. The transcriptional co-activator peroxisome proliferator-activated receptor C coactivator 1alpha (PGC-1alpha), regulates mitochondrial biogenesis and function. Expression of the membrane protein Fibronectin type III domain-containing protein 5 (FNDC5) is stimulated in muscle by PGC-1alpha in response to exercise. FNDC5 is proteolytically cleaved and secreted as the hormone peptide irisin (named after the Greek goddess messenger Iris). Irisin has been shown to convert white adipose fat to brown adipose fat upon physical exertion. Brown adipose fat allows for mitochondrial uncoupling leading to thermogenetic programs and heat expenditure. The physiological responses induced by the effects of irisin have the potential to increase weight loss and reduce insulin resistance and obesity.CAS Number: 9037-90-5. Synonyms: Fibronectin Type III Domain 5, FNDC5, FRCP2, PeP. Purity: >85% estimated by SDS-PAGE. Source: Recombinant protein expressed in E. coli. An N-terminal His-tag and SUMOpro tag were removed by cleavage with SUMO protease 1 (Ulp1).. Amino Acids: 1-111 (full-length, amino acids 32-143 of FNDC5). MW: 12.4 kDa. Formulation: (Request formulation change), 50 mM Tris pH 8.0, 150 mM sodium chloride, and 20% glycerol. License: SUMOpro tag was used under non-exclusive license from LifeSensors, Inc.. UniProt Accession #: Q8NAU1.