FNDC5:Fc (human) (rec.)

FNDC5 (extracellular domain) (human, aa 32-152 / mouse, aa 29-149) is fused at the C-terminus to the Fc portion of human IgG1. FNDC5 (extracellular domain) has 100% identity between mouse, rat and human. Endotoxin Content: <0.01EU/?g purified protein (LAL test, Lonza). Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure. The membrane receptor FNDC5 can be cleaved by an unknown protease to release the Irisin protein (aa 32-143 for human) and potentially also the FNDC5 (extracellular domain, aa 32-153 for human). Human Irisin: Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue. [The Uniprot Consortium]