Fc (human):FasL, Soluble (human) (rec.)

3 x 10 µg. Human FasL (aa 139-281) is fused at the N-terminus to the Fc portion of human IgG1. Lyophilized. Contains PBS. Fc (human):FasL, Soluble (human) is a high activity construct in which two trimeric FasL are artificially linked via the Fc binding domain of human IgG1. This construct very effectively simulates the natural membrane-assisted aggregation of FasL in vivo. FasL is a cytokine that binds to TNFRSF6/Fas, a receptor that transduces the apoptotic signal into cells. It is involved in cytotoxic T cell mediated apoptosis and in T cell development.