Ac-DMQD-CHO (trifluoroacetate salt)

Ac-DMQD-CHO is a peptide inhibitor of caspase-3 (IC50 = 39 nM). It is selective for caspase-3 over caspase-1 and caspase-8 (IC50s = 148 and 1,100 nM, respectively). Ac-DMQD-CHO inhibits apoptosis induced by camptothecin (Cay-11694) in immortalized human T/C 28a4 chondrocytes and primary human chondrocytes. In vivo, Ac-DMQD-CHO (1 mg/kg, i.v.) reduces the number of apoptotic cells, cavitation, and demyelination in a rat model of traumatic injury to the spinal cord.Formal Name: N-acetyl-L-alpha-aspartyl-L-methionyl-N1-[(1S)-2-carboxy-1-formylethyl]-L-glutamamide, trifluoroacetate salt. Synonyms: Ac-Asp-Met-Gln-Asp-CHO, Caspase-3 Inhibitor. Molecular Formula: C20H31N5O10S . XCF3COOH. Formula Weight: 533.6. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Water: 1 mg/ml. SMILES: NC(CC[C@H](NC([C@H](CCSC)NC([C@@H](NC(C)=O)CC(O)=O)=O)=O)C(N[C@H](C=O)CC(O)=O)=O)=O.FC(F)(C(O)=O)F. InChi Code: InChI=1S/C20H31N5O10S.C2HF3O2/c1-10(27)22-14(8-17(31)32)20(35)25-13(5-6-36-2)19(34)24-12(3-4-15(21)28)18(33)23-11(9-26)7-16(29)30,3-2(4,5)1(6)7/h9,11-14H,3-8H2,1-2H3,(H2,21,28)(H,22,27)(H,23,33)(H,24,34)(H,25,35)(H,29,30)(H,31,32),(H,6,7)/t11-,12-,13-,14-,/m0./s1. InChi Key: NLPCSCWRVYMUIO-ZMNOQRQPSA-N.