Mastoparan 7 (trifluoroacetate salt)

Mastoparan 7 is a G protein activator and derivative of the mast cell degranulating peptide mastoparan (Cay-20240). It decreases the affinity of acetylcholine (ACh) to porcine brain muscarinic ACh receptors (mAChRs) when used at a concentration of 30 µM and induces GDP/GTP exchange by Gi in a concentration-dependent manner. Mastoparan 7 (1 µM) also induces activation of Galphao in, and increases dendritic spine density of, primary rat hippocampal neurons. It induces contractions in isolated perfused rat tail arteries (EC50 = 44.1 nM). Immunization with a vaccine against cocaine in combination with mastoparan 7 as an adjuvant increases hapten-specific serum IgG levels and decreases cocaine-induced locomotion in mice.Synonyms: Mas7. Molecular Formula: C67H124N18O15 . XCF3COOH. Formula Weight: 1421.8. Purity: >95%. Formulation: (Request formulation change), A solid. Peptide Sequence: INLKALAALAKALL-NH2. Solubility: Water: Soluble. SMILES: [H]N[C@]([C@H](CC)C)([H])C(N[C@@H](CC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N)=O)=O)=O)C)=O)=O)C)=O)=O)C)=O)C)=O)=O)C)=O)=O)=O)=O.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C67H124N18O15.C2HF3O2/c1-18-38(12)53(71)67(100)85-51(32-52(70)86)66(99)84-50(31-37(10)11)64(97)79-45(24-20-22-26-69)61(94)75-42(16)58(91)82-47(28-34(4)5)62(95)76-39(13)55(88)73-40(14)57(90)81-48(29-35(6)7)63(96)77-41(15)56(89)78-44(23-19-21-25-68)60(93)74-43(17)59(92)83-49(30-36(8)9)65(98)80-46(54(72)87)27-33(2)3,3-2(4,5)1(6)7/h33-51,53H,18-32,68-69,71H2,1-17H3,(H2,70,86)(H2,72,87)(H,73,88)(H,74,93)(H,75,94)(H,76,95)(H,77,96)(H,78,89)(H,79,97)(H,80,98)(H,81,90)(H,82,91)(H,83,92)(H,84,99)(H,85,100),(H,6,7)/t38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,53-,/m0./s1. InChi Key: BJNSONOHGKNLFN-SPJAXDBWSA-N.