H-Arg-Gly-Asp-Cys-OH (trifluoroacetate salt)

H-Arg-Gly-Asp-Cys-OH is a tetrapeptide that contains the arginine-glycine-aspartate (RGD) motif, a sequence that acts as a recognition site for various adhesion proteins. It inhibits the binding of fibrinogen to endothelial cells and ADP-stimulated platelets with IC50 values of 320 and 35 µM, respectively. Implantation of titanium rods coated with H-Arg-Gly-Asp-Cys-OH increases bone formation in rat femurs. H-Arg-Gly-Asp-Cys-OH has been conjugated to polyethylenimine to improve gene transfection efficiency.Formal Name: (6S,12S,15R)-1,6-diamino-12-(carboxymethyl)-1-imino-15-(mercaptomethyl)-7,10,13-trioxo-2,8,11,14-tetraazahexadecan-16-oic acid, trifluoroacetate salt. Synonyms: H-RGDC-OH. Molecular Formula: C15H27N7O7S . XCF3COOH. Formula Weight: 449.5. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Ethanol: 10 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: OC([C@H](CS)NC([C@H](CC(O)=O)NC(CNC([C@@H](N)CCCNC(N)=N)=O)=O)=O)=O.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C15H27N7O7S.C2HF3O2/c16-7(2-1-3-19-15(17)18)12(26)20-5-10(23)21-8(4-11(24)25)13(27)22-9(6-30)14(28)29,3-2(4,5)1(6)7/h7-9,30H,1-6,16H2,(H,20,26)(H,21,23)(H,22,27)(H,24,25)(H,28,29)(H4,17,18,19),(H,6,7)/t7-,8-,9-,/m0./s1. InChi Key: AJFGGKXZCJCXNM-YWUTZLAHSA-N.