Enterostatin (human, mouse, rat) (trifluoroacetate salt)

Enterostatin (human, mouse, rat) (trifluoroacetate salt)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay34624-1 1 mg -

6 - 10 Werktage*

32,00 €
Cay34624-5 5 mg -

6 - 10 Werktage*

118,00 €
Cay34624-10 10 mg -

6 - 10 Werktage*

204,00 €
Cay34624-25 25 mg -

6 - 10 Werktage*

352,00 €
 
Enterostatin is an endogenous pentapeptide fragment involved in the regulation of food intake. It... mehr
Produktinformationen "Enterostatin (human, mouse, rat) (trifluoroacetate salt)"
Enterostatin is an endogenous pentapeptide fragment involved in the regulation of food intake. It is released from its precursor protein, procolipase, during digestion and acts in the peripheral and central nervous systems to reduce food, especially fat, intake through the vagus nerve in the periphery and kappa-opioid-, serotonin (5-HT) receptor subtype 5-HT1B-, and cholecystokinin-mediated signaling pathways in the brain. Enterostatin binds to mitochondrial complex V, also known as F1F0 ATP synthase, in a cell-free assay and inhibits ATP production and increases thermogenesis in INS-1 insulinoma cells. It reduces body weight in rats fed a high-fat diet but not mice fed a chow diet. Enterostatin (1 nmol, i.c.v) reduces food intake in wild-type, but not melanocortin receptor 4 knockout (Mc4r-/-), mice. It also enhances memory consolidation in mice in a passive avoidance test when administered at a dose of 300 mg/kg, an effect that can be blocked by the cholecystokinin 1 (CCK1) receptor antagonist lorglumide (Cay-17555).Formal Name: L-alanyl-L-prolylglycyl-L-prolyl-L-arginine, trifluoroacetate salt. Synonyms: APGPR. Molecular Formula: C21H36N8O6 . XCF3COOH. Formula Weight: 496.6. Purity: >95%. Formulation: A solid. Solubility: DMF: 30 mg/ml, DMSO: 25 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: N=C(N)NCCC[C@@H](C(O)=O)NC([C@H]1N(C(CNC([C@H]2N(C([C@H](C)N)=O)CCC2)=O)=O)CCC1)=O.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C21H36N8O6.C2HF3O2/c1-12(22)19(33)29-10-4-6-14(29)17(31)26-11-16(30)28-9-3-7-15(28)18(32)27-13(20(34)35)5-2-8-25-21(23)24,3-2(4,5)1(6)7/h12-15H,2-11,22H2,1H3,(H,26,31)(H,27,32)(H,34,35)(H4,23,24,25),(H,6,7)/t12-,13-,14-,15-,/m0./s1. InChi Key: HMDSUZSIJATJAB-WFGXUCIJSA-N.
Schlagworte: APGPR, L-alanyl-L-prolylglycyl-L-prolyl-L-arginine, trifluoroacetate salt
Hersteller: Cayman Chemical
Hersteller-Nr: 34624

Eigenschaften

Anwendung: Food intake regulating pentapeptide
Konjugat: No
MW: 496.6 D
Formel: C21H36N8O6 . XCF3COOH
Reinheit: >95%
Format: Solid

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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