Citrullinated Vimentin (R144) (139-159)-biotin Peptide

Citrullinated vimentin (R144) (139-159)-biotin peptide is a biotinylated version of a mono-citrullinated form of the cytoskeleton intermediate filament protein vimentin, which has been found in the synovial fluid of patients with rheumatoid arthritis. Vimentin is subject to citrullination by peptidyl arginine deiminase 2 (PAD2) under high calcium concentrations, which can occur during macrophage apoptosis. Serum levels of immune complexes targeting citrullinated vimentin are increased in patients with rheumatoid arthritis and positive for anti-citrullinated protein antibodies (ACPAs). Serum and plasma levels of citrullinated vimentin are also increased in patients with lung cancer or idiopathic pulmonary fibrosis, respectively. Cayman's Citrullinated Vimentin (R144) (139-159)-biotin Peptide is intended for use in the detection of autoantibodies against vimentin citrullinated at R144.Synonyms: Biotin-GQGKS(Cit)LGDLYEEEMRELRRQ, Biotin-GQGKSXLGDLYEEEMRELRRQ (X=Citrulline), Citrullinated VIM (R144)-biotin. MW: 2,778.0. Formulation: (Request formulation change), 1 mg of lyophilized peptide. UniProt Accession #: P08670.