BRC4wt (trifluoroacetate salt)

BRC4wt is an acetylated peptide derived from the BRC4 repeat in human BRCA2 (1521-1536) and an inhibitor of the protein-protein interaction between BRCA2 and RAD51. When coupled to the cationic cell-penetrating peptide (Arg)9 (Cay-36714), BRC4wt shortens DNA replication tract lengths and reduces homologous repair frequency of DNA damage induced by the DNA topoisomerase I inhibitor camptothecin (Cay-11694) in vitro, as well as potentiates cell death induced by the poly(ADP-ribose) polymerase (PARP) inhibitor olaparib (Cay-10621) in HeLa human cervical cancer and U2OS human osteosarcoma cells but not in non-cancerous hTERT RPE-1, MRC-5, or MCF-10A cells.Formal Name: (S)-2-((5S,8S,11S,14S,17S,23S,26S)-14-((1H-imidazol-5-yl)methyl)-17-benzyl-11-((R)-1-hydroxyethyl)-5-(hydroxymethyl)-23,26-diisobutyl-8-methyl-4,7,10,13,16,19,22,25,28-nonaoxo-3,6,9,12,15,18,21,24,27-nonaazanonacosanamido)-6-amino-N-((5S,8S,11S,14S,17S,20S)-1,24-diamino-14-(4-aminobutyl)-11-((S)-sec-butyl)-5-carbamoyl-17-isopropyl-8-methyl-7,10,13,16,19-pentaoxo-6,9,12,15,18-pentaazatetracosan-20-yl)hexanamide, trifluoroacetate salt. Molecular Formula: C81H139N23O19 . XCF3COOH. Formula Weight: 1739.1. Purity: >98%. Formulation: (Request formulation change), A solid. Peptide Sequence: Ac-LLGFHTASGKKVKIAK-NH2. Solubility: Water: Soluble. SMILES: NC([C@H](CCCCN)NC([C@@H](NC([C@@]([C@H](CC)C)([H])NC([C@H](CCCCN)NC([C@H](C(C)C)NC([C@H](CCCCN)NC([C@H](CCCCN)NC(CNC([C@H](CO)NC([C@@H](NC([C@@]([C@@H](C)O)([H])NC([C@@H](NC([C@@H](NC(CNC([C@H](CC(C)C)NC([C@H](CC(C)C)NC(C)=O)=O)=O)=O)CC1=CC=CC=C1)=O)CC2=CN=CN2)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C81H139N23O19.C2HF3O2/c1-13-47(8)66(80(122)91-48(9)69(111)96-54(68(86)110)27-17-21-31-82)103-75(117)57(30-20-24-34-85)98-79(121)65(46(6)7)102-74(116)56(29-19-23-33-84)97-73(115)55(28-18-22-32-83)94-63(108)40-89-72(114)62(42-105)101-70(112)49(10)92-81(123)67(50(11)106)104-78(120)61(38-53-39-87-43-90-53)100-77(119)60(37-52-25-15-14-16-26-52)95-64(109)41-88-71(113)58(35-44(2)3)99-76(118)59(36-45(4)5)93-51(12)107,3-2(4,5)1(6)7/h14-16,25-26,39,43-50,54-62,65-67,105-106H,13,17-24,27-38,40-42,82-85H2,1-12H3,(H2,86,110)(H,87,90)(H,88,113)(H,89,114)(H,91,122)(H,92,123)(H,93,107)(H,94,108)(H,95,109)(H,96,111)(H,97,115)(H,98,121)(H,99,118)(H,100,119)(H,101,112)(H,102,116)(H,103,117)(H,104,120),(H,6,7)/t47-,48-,49-,50+,54-,55-,56-,57-,58-,59-,60-,61-,62-,65-,66-,67-,/m0./s1. InChi Key: OQBACIUJSFOCAS-QTTULFAFSA-N.