ZM 306416

ZM 306416 is an inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinase that antagonizes the activity of KDR and Flt VEGF receptors with IC50 values of 100 nM and 2 µM, respectively. It has also been reported to inhibit EGFR kinase with an IC50 value of < 10 nM, reducing proliferation of EGFR-dependent cancer cells.Formal Name: N-(4-chloro-2-fluorophenyl)-6,7-dimethoxy-4-quinazolinamine. CAS Number: 690206-97-4. Synonyms: CB-676475. Molecular Formula: C16H13ClFN3O2. Formula Weight: 333.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 50 mg/ml, DMSO: 50 mg/ml, Ethanol: 20 mg/ml. lambdamax: 219, 250, 331 nm. SMILES: COC1=C(OC)C=C(C(NC2=CC=C(Cl)C=C2F)=NC=N3)C3=C1. InChi Code: InChI=1S/C16H13ClFN3O2/c1-22-14-6-10-13(7-15(14)23-2)19-8-20-16(10)21-12-4-3-9(17)5-11(12)18/h3-8H,1-2H3,(H,19,20,21). InChi Key: YHUIUSRCUKUUQA-UHFFFAOYSA-N.