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Sorafenib
Sorafenib

Artikelnummer: LKT-S5868.25

c-Raf, Ret, VEGFR2 inhibitor, potential STAT3/5 inhibitor, potential HMT inhibitor.
Schlagworte: 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide
Anwendung: BRAF / FLT3 / PDGFRB / VEGFR2 / VEGFR3 / c-KIT inhibitor
Reaktivität: 56
CAS 284461-73-0
MW: 464.82 D
ab 78,00 €
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GW-806742X
GW-806742X

Artikelnummer: SYN-1215-M001

Soluble in DMSO. Potent protein kinase VEGFR2 inhibitor (2nm range). Binds to the pseudokinase domain of MLKL and blocks cell death by necroptosis, as well. With regards to its role in necroptosis, it is an ATP-mimetic that was shown to bind recombinant mouse MLKL pseudokinase domain, which showed inhibited...
Schlagworte: GW806742X, AC1NS7PT, AGN-PC-0LQ49Y
Anwendung: VEGFR2 inhibitor
CAS 579515-63-2
MW: 573,6 D
ab 119,00 €
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Human VEGF Receptor 2/VEGF R2/FLK-1/KDR (C-6His-Avi) Biotinylated
Human VEGF Receptor 2/VEGF R2/FLK-1/KDR (C-6His-Avi)...

Artikelnummer: E-PKSH033969.100

Protein Construction: Biotinylated Recombinant Human Vascular Endothelial Growth Factor Receptor 2 is produced by our Mammalian expression system and the target gene encoding Ala20-Glu764 is expressed with a 6His, Avi tag at the C-terminus. Sequence: Ala20-Glu764. Fusion tag: C-6His-Avi Endotoxin: < 1.0 EU per µg as...
Schlagworte: KDR, FLK1, FLK-1, CD309, VEGFR-2, EC=2.7.10.1, Fetal liver kinase 1, Kinase insert domain receptor, Protein-tyrosine...
MW: 86.1 kD
ab 373,00 €
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Vandetanib, Free Base
Vandetanib, Free Base

Artikelnummer: LC-V-9402_100mg

Solubility: Soluble in DMSO at 30 mg/mL, soluble in ethanol at 10 mg/mL with warming, very poorly soluble in water, maximum solubility in plain water is estimated to be about 10-20 µM, buffers, serum, or other additives may increase or decrease the aqueous solubility. Vandetanib inhibits VEGFR-dependent tumor...
Schlagworte: ZD6474
Anwendung: VEGFR / EGFR Kinase inhibitor
CAS 443913-73-3
MW: 475,35 D
ab 82,00 €
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DMXAA
DMXAA

Artikelnummer: Cay14617-1

DMXAA is a xanthene which acts as a tumor vascular disrupting agent, inducing apoptosis in tumor vascular endothelium resulting in necrosis at the tumor core. It potently activates the TANK-binding kinase 1-interferon regulatory factor 3 (TBK1/IRF3) signaling pathway in leukocytes, inducing type-I-interferon (IFN)...
Schlagworte: 5,6-Dimethylxanthenone-4-acetic Acid, ASA 404, NSC 640488, Vadimezan, 5,6-dimethyl-9-oxo-9H-xanthene-4-acetic acid
Anwendung: VEGFR2 inhibitor, Apoptosis inducer
CAS 117570-53-3
MW: 282.3 D
ab 32,00 €
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XL184
XL184

Artikelnummer: Cay18464-1

XL184 is a pan tyrosine kinase inhibitor that primarily targets VEGFR2 (IC50 = 0.035 nM) and c-Met (IC50 = 1.3 nM) but also inhibits RET, c-Kit, Axl, FLT3, and Tie2 (IC50s = 5.2, 4.6, 7, 11.3, and 14.3 nM, respectively). In in vivo breast, lung, and glioma tumor models that represent dysregulated c-Met and VEGFR...
Schlagworte: BMS-907351, Cabozantinib, N'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide
Anwendung: Pan tyrosine kinase inhibitor
CAS 849217-68-1
MW: 501.5 D
ab 44,00 €
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ODM-203
ODM-203

Artikelnummer: Cay31451-25

ODM-203 is a dual inhibitor of VEGFR and FGFR (IC50s = 5-26 and 6-35 nM for VEGFR1-3 and FGFR1-4, respectively). It is selective for VEGFR1-3 and FGFR1-4 over a panel of 308 kinases at 1 µM, but does inhibit the receptor tyrosine kinases PDGFRalpha, PDGFRbeta, and DDR1 (IC50s = 35, 169, and 6 nM, respectively), as...
Schlagworte: N-[2',4'-difluoro-5-[5-(1-methyl-1H-pyrazol-4-yl)-1H-benzimidazol-1-yl][1,1'-biphenyl]-3-yl]-cyclopropanesulfonamide
Anwendung: VEGFR / FGFR dual inhibitor
CAS 1430723-35-5
MW: 505.5 D
ab 124,00 €
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SU 14813
SU 14813

Artikelnummer: Cay31514-5

SU 14813 is a dual VEGFR and PDGFR family kinase inhibitor (IC50s = 0.002, 0.05, 0.004, and 0.015 µM for VEGFR1, VEGFR2, PDGFRbeta, and KIT, respectively). It is selective for these kinases over FGFR1, EGFR, Src, and c-Met (IC50s = 3.5, >20, 2.5, and 9 µM, respectively). SU 14813 inhibits VEGFR2, PDGFRbeta, KIT, and...
Schlagworte: 5-[(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-1H-pyrro...
Anwendung: Dual VEGFR / PDGFR family kinase inhibitor
CAS 627908-92-3
MW: 442.5 D
ab 57,00 €
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Foretinib
Foretinib

Artikelnummer: LKT-F5968.5

Foretinib is an inhibitor of ROS1, MET, Ron, Axl, Tie-2, and VEGFR2 that exhibits anticancer chemotherapeutic and anti-angiogenic activities. In subjects with squamous cell carcinoma, foretinib decreases tumor size. In hepatocellular carcinoma cells, foretinib increases expression of p27 and Bim, decreases...
Schlagworte: GSK-1363089, GSK1363089
Anwendung: VEGFR2 tyrosine kinase inhibitor, Met proto-oncogene (c-Met) inhibitor
CAS 849217-64-7
MW: 632.65 D
ab 109,00 €
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Vandetanib
Vandetanib

Artikelnummer: Cay14706-10

Vandetanib is a broad spectrum, orally available kinase inhibitor that targets primarily tyrosine kinases, including vascular endothelial growth factor receptor (VEGFR) and epidermal growth factor receptor (EGFR), with IC50 values in the nanomolar range. It also potently blocks non-receptor tyrosine kinases,...
Schlagworte: Caprelsa(R), CH 331, Zactima, ZD 6474,...
Anwendung: VEGFR / EGFR Kinase inhibitor
CAS 443913-73-3
MW: 475.4 D
ab 37,00 €
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Dovitinib
Dovitinib

Artikelnummer: Cay15220-10

Dovitinib is a receptor tyrosine kinase inhibitor that targets vascular endothelial growth factor-2, basic fibroblast growth factor-1, and platelet-derived growth factor beta receptors (IC50s = 65, 11, and 5 nM, respectively). By impairing these kinase signals, 1 µM dovitinib has been shown to prevent the growth and...
Schlagworte: 4-amino-5-fluoro-3-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-2(1H)-quinolinone
Anwendung: PDGFRB / VEGFR2 / FGFR1 inhibitor
CAS 405169-16-6
MW: 392.4 D
ab 124,00 €
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RAF265
RAF265

Artikelnummer: Cay16991-1

RAF265 is a dual inhibitor of mutant B-RafV600E and vascular endothelial growth factor receptor 2 (EC50s = 0.14 and 0.19 µM, respectively, in cell-based assays). It can also inhibit wild-type B-Raf, platelet-derived growth factor receptor, colony-stimulating factor 1R, RET, c-KIT, SRC, and STE20 with IC50 values...
Schlagworte: CHIR265,...
Anwendung: B-Raf V600E / VEGFR2 inhibitor
CAS 927880-90-8
MW: 518.4 D
ab 44,00 €
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