Zu "K05098" wurden 335 Artikel gefunden!
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![TGFBR1 mFc Chimera[Biotin], Avi, Human](https://www.biomol.com/media/image/70/de/fc/GSC-Z04621-100_200x200.png "TGFBR1 mFc Chimera[Biotin], Avi, Human")
TGFBR1 mFc Chimera[Biotin], Avi, Human
Artikelnummer: GSC-Z04621-100
transforming growth factor beta receptor 1 (TGFBR1), a key stimulator of tumor proliferation and metastasis, was a direct target of miR-98-5p. miR-98-5p overexpression resulted in the downregulation of TGFBR1 and the suppression of the viability, proliferation, migration and invasion of A549 and H1299 cells.
| Schlagworte: | KDR, Fetal liver kinase 1, Kinase insert domain receptor, Protein-tyrosine kinase receptor flk-1, Vascular endothelial... |
| Ursprungsart: | human |
| MW: | 38.2 kD |
ab 887,00 €
Human VEGFR2 ELISA Kit
Artikelnummer: ARG81425.96
Protein function: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of...
| Schlagworte: | KDR, FLK1, CD309, FLK-1, VEGFR-2, EC=2.7.10.1, Fetal liver kinase 1, Kinase insert domain receptor, Protein-tyrosine... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
1.118,00 €
VEGFR2, Avi & His, Human
Artikelnummer: GSC-Z03811-100
The kinase insert domain receptor (KDR), also known as vascular endothelial growth factor receptor 2 (VEGFR-2), is a type IV receptor tyrosine kinase that plays a crucial role in various biological processes, including embryonic vasculature development, angiogenesis regulation, cell survival, migration, macrophage...
| Schlagworte: | KDR, Fetal liver kinase 1, Kinase insert domain receptor, Protein-tyrosine kinase receptor flk-1, Vascular endothelial... |
| Ursprungsart: | human |
| MW: | 86.2 kD |
ab 403,00 €
VEGF-R2 Fc Chimera, Mouse
Artikelnummer: GSC-Z03555-1
VEGF-R2 belongs to a family of proteins called receptor tyrosine kinases. The receptor has three main parts: one part extends out of the cell and binds to VEGF, another spans the cell's membrane, while the third part is found inside the cell. The current model of VEGF-R2 activation is that VEGF binds to individual...
| Schlagworte: | Kdr, Kinase NYK, Fetal liver kinase 1, Protein-tyrosine kinase receptor flk-1, Vascular endothelial growth factor receptor 2 |
| Ursprungsart: | mouse |
ab 161,00 €
BMS 605541
Artikelnummer: Cay43119-10
A VEGFR2 inhibitor (IC50 = 23 nM), selective for VEGFR2 over 22 other kinases (IC50s = 400->10,000 nM), inhibits VEGF-induced proliferation in HUVECs (IC50 = 25 nM), decreases tumor volume in an L2987 lung adenocarcinoma mouse xenograft model at 90 or 180 mg/kg per day
| Schlagworte: | N-cyclopropyl-2,4-difluoro-5-[[[2-(2-pyridinylamino)-5-thiazolyl]methyl]amino]-benzamide |
| Anwendung: | VEGFR2 inhibitor |
| CAS | 639858-32-5 |
| MW: | 401.44 D |
ab 118,00 €
ZD 4190
Artikelnummer: Cay42248-1
A VEGFR1, VEGFR2, and EGFR inhibitor (IC50s = 0.7, 0.03, and 0.4 µM, respectively), selective for these kinases over PDGFRbeta, FGFR1, and HER2 (IC50s = 3.4, >100, and >100 µM, respectively) and MEK, Cdk2, IGF-1R, Akt, and Tie2 (IC50s = >10, >10, >20, >20, and >100 µM, respectively), selectively inhibits VEGF- or...
| Schlagworte: | N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[2-(1H-1,2,3-triazol-1-yl)ethoxy]-4-quinazolinamine |
| Anwendung: | VEGFR1/VEGFR2/EGFR inhibitor |
| CAS | 413599-62-9 |
| MW: | 459.3 D |
ab 73,00 €
Sorafenib
Artikelnummer: LKT-S5868.25
c-Raf, Ret, VEGFR2 inhibitor, potential STAT3/5 inhibitor, potential HMT inhibitor.
| Schlagworte: | 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide |
| Anwendung: | BRAF / FLT3 / PDGFRB / VEGFR2 / VEGFR3 / c-KIT inhibitor |
| CAS | 284461-73-0 |
| MW: | 464.82 D |
ab 109,00 €
Tie2/VEGFR2 Kinase-IN-2
Artikelnummer: Cay42544-10
Tie2/VEGFR2 kinase-IN-2 is an inhibitor of tunica interna endothelial cell kinase 2 (Tie2) and VEGFR2 (IC50s = 13. and 7. nM, respectively). It is selective for Tie2 and VEGFR2 over Akt3, cyclin-dependent kinase 2 (Cdk2), EGFR, and glycogen synthase kinase 3 (GSK3, IC50s = >10,000, >10,000, 10,000, and 2,187 nM,...
| Schlagworte: | Tie2/Vascular Endothelial Growth Factor Receptor 2 Kinase Inhibitor 2, Tie2/Vascular Endothelial Growth Factor Receptor 2... |
| Anwendung: | Tie2 / VEGFR inhibitor |
| CAS | 501693-48-7 |
| MW: | 431.34 D |
ab 236,00 €
Anti-VEGFR2 Rabbit (Clone RM515)
Artikelnummer: Cay42781-100
VEGFR2, also known as kinase insert domain receptor (KDR), is a receptor tyrosine kinase that has roles in vascular permeability, cell proliferation and survival, and angiogenesis. It is composed of an N-terminal extracellular ligand-binding domain, which contains seven immunoglobulin-like (Ig-like) domains, a...
| Schlagworte: | CD309, Fetal Liver Kinase 1, FLK1, KDR, Kinase Insert Domain Receptor, Vascular Endothelial Growth Factor Receptor 2 |
| Anwendung: | IHC, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
554,00 €
GW-806742X
Artikelnummer: SYN-1215-M001
Soluble in DMSO. Potent protein kinase VEGFR2 inhibitor (2nm range). Binds to the pseudokinase domain of MLKL and blocks cell death by necroptosis, as well. With regards to its role in necroptosis, it is an ATP-mimetic that was shown to bind recombinant mouse MLKL pseudokinase domain, which showed inhibited...
| Schlagworte: | GW806742X, AC1NS7PT, AGN-PC-0LQ49Y |
| Anwendung: | VEGFR2 inhibitor |
| CAS | 579515-63-2 |
| MW: | 573,6 D |
ab 139,00 €
VEGFR2(KDR) Kinase Assay Kit
Artikelnummer: BPS-40325
Vascular endothelial growth factor receptor 2 (VEGFR2), also called Kinase insert Domain receptor (KDR), is a tyrosine kinase (TK) receptor for VEGFs that plays a central role in tumor angiogenesis, therefore the inhibition of VEGFR2 is a promising therapeutic strategy for inhibiting angiogenesis and tumor growth....
| Schlagworte: | KDR, Kinase Insert Domain Receptor, VEGFR2, Vascular Endothelial Growth Factor Receptor 2, CD309, FLK-1, Fetal Liver... |
| Anwendung: | Enzyme kinetics, drug discovery, HTS |
| Spezies-Reaktivität: | human |
842,00 €
XL184
Artikelnummer: Cay18464-1
XL184 is an inhibitor of VEGFR2 (IC50 = 0.035 nM). It is selective for VEGFR2 over Ron, EGFR, IGF-1R, and EphA4/B4, but also inhibits c-Met, RET, c-Kit, Axl, FLT3, and Tie2 (IC50s = 1.3, 5.2, 4.6, 7, 11.3, and 14.3 nM, respectively). XL184 (4.6 nM) inhibits VEGF-induced tubule formation in human microvascular...
| Schlagworte: | BMS-907351, Cabozantinib, N'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide |
| Anwendung: | Pan tyrosine kinase inhibitor |
| CAS | 849217-68-1 |
| MW: | 501.5 D |
ab 67,00 €