TBCA

Casein kinase 2 (CK2) is a kinase with many targets and diverse roles in cell signaling and disease. TBCA is a selective, cell-permeable inhibitor of CK2 (IC50 = 0.11 µM, Ki = 77 nM) that has minimal effect on a panel of 28 other kinases. It induces cell death in Jurkat adult T cell leukemia cells (DC50 = 7.7 µM), driving caspase-dependent degradation of poly-ADP ribose polymerase while inhibiting CK2 activity. TBCA also supports a role for CK2 in platelet function and Akt phosphorylation but not protein splicing.Formal Name: (2E)-3-(2,3,4,5-tetrabromophenyl)-2-propenoic acid. CAS Number: 934358-00-6. Synonyms: Casein Kinase II Inhibitor III, Tetrabromocinnamic Acid. Molecular Formula: C9H4Br4O2. Formula Weight: 463.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 2 mg/ml, Ethanol: 1 mg/ml. lambdamax: 237, 278 nm. SMILES: BrC1=C(Br)C(Br)=C(Br)C=C1/C=C/C(O)=O. InChi Code: InChI=1S/C9H4Br4O2/c10-5-3-4(1-2-6(14)15)7(11)9(13)8(5)12/h1-3H,(H,14,15)/b2-1+. InChi Key: SVJQCVOKYJWUBC-OWOJBTEDSA-N.