SZL P1-41

SZL P1-41 is an inhibitor of the Skp1-Cullin1-F-box (SCF) family protein Skp2. It inhibits the interaction between Skp2 and Skp1 to block Skp2 E3 ubiquitin ligase activity when used at a concentration of 5 µM. SZL P1-41 selectively inhibits Skp2 over Fbw7 and beta-TrCP E3 ubiquitin ligase activity in HEK293T cells. It reduces survival of LNCaP and PC3 prostate cancer cells in a concentration-dependent manner via inhibition of aerobic glycolysis and induction of apoptosis. SZL P1-41 (40 and 80 mg/kg) reduces tumor volume in A549 lung cancer and PC3 prostate cancer mouse xenograft models.Formal Name: 3-(2-benzothiazolyl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)-4H-1-benzopyran-4-one. CAS Number: 222716-34-9. Molecular Formula: C24H24N2O3S. Formula Weight: 420.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMSO: 0.3 mg/ml, Ethanol: 0.3 mg/ml. lambdamax: 224, 264, 308. SMILES: O=C1C(C2=NC3=C(C=CC=C3)S2)=COC4=C1C=C(CC)C(O)=C4CN5CCCCC5. InChi Code: InChI=1S/C24H24N2O3S/c1-2-15-12-16-22(28)18(24-25-19-8-4-5-9-20(19)30-24)14-29-23(16)17(21(15)27)13-26-10-6-3-7-11-26/h4-5,8-9,12,14,27H,2-3,6-7,10-11,13H2,1H3. InChi Key: JKIXLEKBXHMXTN-UHFFFAOYSA-N.