SC144 (hydrochloride)

SC144 is an orally bioavailable gp130 inhibitor. It inhibits phosphorylation of STAT1, STAT3, and Akt induced by leukemia inhibitory factor (LIF) and IL-6, but not IFN-gamma, in OVCAR-8 ovarian cancer cells when used at a concentration of 20 µM. SC144 induces cell cycle arrest at the G0/G1 phase in MDA-MB-435 breast and HT-29 colorectal cancer cells and inhibits proliferation of 14 cancer cell lines, including prostate, ovarian, lung, breast, and colorectal cancer cells, with IC50 values ranging from 0.4 to 4 µM. It reduces tumor growth in OVCAR-8 and MDA-MB-435 mouse xenograft models.Formal Name: 2-pyrazinecarboxylic acid, 2-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)hydrazide, monohydrochloride. CAS Number: 917497-70-2. Molecular Formula: C16H11FN6O . HCl. Formula Weight: 358.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2 mg/ml, DMSO: 5 mg/ml. lambdamax: 269, 314 nm. SMILES: FC1=CC=C2C(N=C(NNC(C3=NC=CN=C3)=O)C4=CC=CN42)=C1.Cl. InChi Code: InChI=1S/C16H11FN6O.ClH/c17-10-3-4-13-11(8-10)20-15(14-2-1-7-23(13)14)21-22-16(24)12-9-18-5-6-19-12,/h1-9H,(H,20,21)(H,22,24),1H. InChi Key: LKFGGXYXFIICED-UHFFFAOYSA-N.