Zu "917497-70-2" wurden 2 Artikel gefunden!
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SC144 hydrochloride
Artikelnummer: TGM-T41260-2mg
Description: SC144 hydrochloride, a first-in-class, orally active, small-molecule gp130 (IL6-beta) inhibitor, demonstrates potent inhibition of gp130 ligand-triggered signaling. By binding to gp130, it initiates gp130 phosphorylation (S782) and deglycosylation, impedes Stat3 phosphorylation and nuclear...
| Anwendung: | gp130 inhibitor |
| CAS | 917497-70-2 |
| MW: | 358.76 D |
54,00 €
SC144 (hydrochloride)
Artikelnummer: Cay29714-1
SC144 is an orally bioavailable gp130 inhibitor. It inhibits phosphorylation of STAT1, STAT3, and Akt induced by leukemia inhibitory factor (LIF) and IL-6, but not IFN-gamma, in OVCAR-8 ovarian cancer cells when used at a concentration of 20 µM. SC144 induces cell cycle arrest at the G0/G1 phase in MDA-MB-435 breast...
| Schlagworte: | 2-pyrazinecarboxylic acid, 2-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)hydrazide, monohydrochloride |
| Anwendung: | gp130 inhibitor |
| CAS | 917497-70-2 |
| MW: | 358.8 D |
ab 44,00 €
