LY2606368

LY2606368 is a checkpoint kinase 1 (Chk1) inhibitor with a Ki value of 0.9 nM against the purified target and IC50 values of In vitro, LY2606368 inhibits the doxorubicin-activated G2/M checkpoint in p53-deficient HeLa cells with an EC50 value of 9 nM. LY2606368, at 25 nM, also significantly induces apoptosis and inhibits colony formation in AGS and MKN1 gastric cancer cells.Formal Name: 5-[[5-[2-(3-aminopropoxy)-6-methoxyphenyl]-1H-pyrazol-3-yl]amino]-2-pyrazinecarbonitrile. CAS Number: 1234015-52-1. Synonyms: Prexasertib. Molecular Formula: C18H19N7O2. Formula Weight: 365.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. lambdamax: 214, 295 nm. SMILES: NCCCOC1=C(C2=CC(N([H])C3=NC=C(C#N)N=C3)=NN2[H])C(OC)=CC=C1. InChi Code: InChI=1S/C18H19N7O2/c1-26-14-4-2-5-15(27-7-3-6-19)18(14)13-8-16(25-24-13)23-17-11-21-12(9-20)10-22-17/h2,4-5,8,10-11H,3,6-7,19H2,1H3,(H2,22,23,24,25). InChi Key: DOTGPNHGTYJDEP-UHFFFAOYSA-N.