Zu "K02216" wurden 145 Artikel gefunden!
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SAR-020106
Artikelnummer: SYN-1189-M001
Soluble in DMSO. SAR-020106 is an ATP-competitive, potent, and selective CHK1 inhibitor with an IC(50) of 13.3nM on the isolated human enzyme. This compound abrogates an etoposide-induced G(2) arrest with an IC(50) of 55nM in HT29 cells, and significantly enhances the cell killing of gemcitabine and SN38 by 3.0- to...
| Schlagworte: | SAR020106 |
| Anwendung: | Chk1 inhibitor |
| CAS | 1184843-57-9 |
| MW: | 382,9 D |
ab 293,00 €
Anti-CHEK1
Artikelnummer: ABS-KC-1719.100
Protein function: Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA (PubMed:11535615, PubMed:12446774, PubMed:12399544, PubMed:14559997, PubMed:14988723, PubMed:15311285,...
| Schlagworte: | Anti-Serine/threonine-protein kinase Chk1, Anti-CHK1 checkpoint homolog, Anti-Cell cycle checkpoint kinase,... |
| Anwendung: | IP |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 206,00 €
Anti-CHEK1
Artikelnummer: ABS-KC-835.100
Protein function: Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA (PubMed:11535615, PubMed:12446774, PubMed:12399544, PubMed:14559997, PubMed:14988723, PubMed:15311285,...
| Schlagworte: | Anti-Serine/threonine-protein kinase Chk1, Anti-CHK1 checkpoint homolog, Anti-Cell cycle checkpoint kinase,... |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 232,00 €
Anti-CHEK1
Artikelnummer: ABS-KC-905.100
Protein function: Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA (PubMed:11535615, PubMed:12446774, PubMed:12399544, PubMed:14559997, PubMed:14988723, PubMed:15311285,...
| Schlagworte: | Anti-Serine/threonine-protein kinase Chk1, Anti-CHK1 checkpoint homolog, Anti-Cell cycle checkpoint kinase,... |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 232,00 €
Anti-CHEK1
Artikelnummer: ABS-KC-990.100
Protein function: Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA (PubMed:11535615, PubMed:12446774, PubMed:12399544, PubMed:14559997, PubMed:14988723, PubMed:15311285,...
| Schlagworte: | Anti-Serine/threonine-protein kinase Chk1, Anti-CHK1 checkpoint homolog, Anti-Cell cycle checkpoint kinase,... |
| Anwendung: | IHC |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 206,00 €
LY2606368
Artikelnummer: Cay21490-1
LY2606368 is a checkpoint kinase 1 (Chk1) inhibitor with a Ki value of 0.9 nM against the purified target and IC50 values of In vitro, LY2606368 inhibits the doxorubicin-activated G2/M checkpoint in p53-deficient HeLa cells with an EC50 value of 9 nM. LY2606368, at 25 nM, also significantly induces apoptosis and...
| Schlagworte: | Prexasertib, 5-[[5-[2-(3-aminopropoxy)-6-methoxyphenyl]-1H-pyrazol-3-yl]amino]-2-pyrazinecarbonitrile |
| Anwendung: | CHK1 inhibitor |
| CAS | 1234015-52-1 |
| MW: | 365.4 D |
ab 35,00 €
CHIR-124
Artikelnummer: TGM-T6350-100mg
Description: CHIR-124 is an effective Chk1 inhibitor (IC50: 0.3 nM). It has 2, 000-fold selectivity against Chk2, 500- to 5, 000-fold less activity against Cdc2 and CDK2/4. Target: GSK-3, Apoptosis, FLT, Chk, PDGFR, Src. Smiles: Clc1ccc2[nH]c(=O)c(-c3nc4ccccc4[nH]3)c(N[C@@H]3CN4CCC3CC4)c2c1. References: Tse AN,...
| Schlagworte: | CHIR124, CHIR 124 |
| Anwendung: | Cell-permeable Chk1 inhibitor |
| CAS | 405168-58-3 |
| MW: | 419.91 D |
ab 37,00 €
Rabusertib
Artikelnummer: TGM-T6084-100mg
Description: Rabusertib (IC-83) is an inhibitor of the cell cycle checkpoint kinase 1 (chk1) with potential chemopotentiating activity. Rabusertib has been used in trials studying the treatment of Cancer, Solid Tumors, Advanced Cancer, Pancreatic Neoplasms, and Non-Small Cell Lung Cancer. Target: Chk, Autophagy,...
| Schlagworte: | LY2603618, IC-83 |
| Anwendung: | Targets serine/threonine-protein kinase CHEK1 [EC:2.7.11.1] (CHEK1) |
| CAS | 911222-45-2 |
| MW: | 436.3 D |
ab 40,00 €
CHK1 inhibitor
Artikelnummer: TGM-T10793-100mg
Description: CHK1 inhibitor (GDC-0575 analog) functions as a CHK1 inhibitor. Target: Chk. Smiles: N(C(=O)C1CC1)C=2C3=C(C(Br)=CC=C3NC2)N4C[C@H](N)CCC4
| Schlagworte: | GDC-0575 analog |
| Anwendung: | CHK1 inhibitor |
| CAS | 2097938-64-0 |
| MW: | 377.28 D |
ab 2.272,00 €
PD 407824
Artikelnummer: TGM-T16446-1mg
Description: PD 407824 is a chemical BMP sensitiser that promotes increased cellular sensitivity to subthreshold amounts of BMP4.PD 407824 is a potent inhibitor of the checkpoint kinases Chk1 and WEE1 (IC50s: 47 and 97 nM, respectively). Target: Chk, Wee1. Smiles: Oc1ccc2[nH]c3cc(c4C(=O)NC(=O)c4c3c2c1)-c1ccccc1....
| Schlagworte: | PD-407824 |
| Anwendung: | Chk1 / WEE1 inhibitor |
| CAS | 622864-54-4 |
| MW: | 328.32 D |
69,00 €
CCT244747
Artikelnummer: TGM-T14904-2mg
Description: CCT244747 is a CHK1 inhibitor (IC50: 7.7 nM) and also abrogates G2 checkpoint (IC50: 29 nM). Target: Chk. Smiles: COc1cc(Nc2cnc(C#N)c(O[C@H](C)CN(C)C)n2)ncc1-c1cnn(C)c1. References: Lainchbury M, et al. Discovery of 3-alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitriles as selective, orally...
| Anwendung: | Chk1 inhibitor |
| CAS | 1404095-34-6 |
| MW: | 408.46 D |
75,00 €
SB-218078
Artikelnummer: TGM-T16848-1mg
Description: SB-218078 is less potently inhibits Cdc2 (IC50: 250 nM) and PKC (IC50: 1000 nM). SB-218078 is a potent, ATP-competitive, and cell-permeable checkpoint kinase 1 inhibitor that inhibits Chk1 phosphorylation of cdc25C (IC50: 15 nM). Target: PKC, Chk. Smiles:...
| Anwendung: | Chk1 inhibitor |
| CAS | 135897-06-2 |
| MW: | 393.39 D |
352,00 €