Zu "K02216" wurden 126 Artikel gefunden!
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SAR-020106
Artikelnummer: SYN-1189-M001
Soluble in DMSO. SAR-020106 is an ATP-competitive, potent, and selective CHK1 inhibitor with an IC(50) of 13.3nM on the isolated human enzyme. This compound abrogates an etoposide-induced G(2) arrest with an IC(50) of 55nM in HT29 cells, and significantly enhances the cell killing of gemcitabine and SN38 by 3.0- to...
| Schlagworte: | SAR020106 |
| Anwendung: | Chk1 inhibitor |
| CAS | 1184843-57-9 |
| MW: | 382,9 D |
ab 250,00 €
Mouse CHEK1 (Checkpoint Kinase 1) ELISA Kit
Artikelnummer: ELK-ELK8049.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse CHEK1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse CHEK1. Next,...
| Schlagworte: | Chk1, Chek1, Checkpoint kinase-1, CHK1 checkpoint homolog, Serine/threonine-protein kinase Chk1 |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | mouse |
ab 365,00 €
Anti-Chk1
Artikelnummer: A300-162A
Protein function: Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. This regulation is achieved by...
| Schlagworte: | Anti-CHK1, Anti-CHEK1, EC=2.7.11.1, Anti-Checkpoint kinase-1, Anti-CHK1 checkpoint homolog, Anti-Cell cycle checkpoint... |
| Anwendung: | WB, IP |
| Wirt: | Goat |
| Spezies-Reaktivität: | human |
ab 164,00 €
Anti-Chk1
Artikelnummer: A300-161A
Protein function: Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. This regulation is achieved by...
| Schlagworte: | Anti-CHK1, Anti-CHEK1, EC=2.7.11.1, Anti-Checkpoint kinase-1, Anti-CHK1 checkpoint homolog, Anti-Cell cycle checkpoint... |
| Anwendung: | WB, IP |
| Wirt: | Goat |
| Spezies-Reaktivität: | human |
ab 164,00 €
Anti-phospho-Chk1 (Ser317)
Artikelnummer: A304-673A
Protein function: Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. This regulation is achieved by...
| Schlagworte: | Anti-phospho-CHK1, Anti-phospho-CHEK1, EC=2.7.11.1, Anti-phospho-Checkpoint kinase-1, Anti-phospho-CHK1 checkpoint... |
| Anwendung: | WB, IP, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 164,00 €
CHIR124
Artikelnummer: Cay16553-1
Checkpoint kinase 1 (Chk1) regulates S and G2-M phase cell cycle checkpoints in response to DNA damage. CHIR124 is a cell-permeable, quinolone-based inhibitor of Chk1 (IC50 = 0.3 nM in vitro). It demonstrates high selectivity for Chk1 by displaying inhibitory values 2,000-fold higher against Chk2 (IC50 = 0.7 µM). In...
| Schlagworte: | 4-[(3S)-1-azabicyclo[2.2.2]oct-3-ylamino]-3-(1H-benzimidazol-2-yl)-6-chloro-2(1H)-quinolinone |
| Anwendung: | Cell-permeable Chk1 inhibitor |
| CAS | 405168-58-3 |
| MW: | 419.9 D |
ab 48,00 €
LY2603618
Artikelnummer: Cay20351-5
LY2603618 is a checkpoint kinase 1 (Chk1) inhibitor (IC50 = 7 nM) that prevents the repair of DNA caused by DNA-damaging agents. It can inhibit Chk1 autophosphorylation and increase DNA damage-mediated Chk1 phosphorylation. LY2603618 has been used in xenograft tumor models to potentiate the antitumor efficacy of...
| Schlagworte: | IC-83, Rabusertib, N-[5-bromo-4-methyl-2-[(2S)-2-morpholinylmethoxy]phenyl]-N'-(5-methyl-2-pyrazinyl)-urea |
| Anwendung: | Antineoplastic, CHEK1 inhibitor |
| CAS | 911222-45-2 |
| MW: | 436.3 D |
ab 54,00 €
Anti-Chk1
Artikelnummer: A300-298A-T
Protein function: Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. This regulation is achieved by...
| Schlagworte: | Anti-CHK1, Anti-CHEK1, EC=2.7.11.1, Anti-Checkpoint kinase-1, Anti-CHK1 checkpoint homolog, Anti-Cell cycle checkpoint... |
| Anwendung: | WB, IP, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 164,00 €
CHK1, active human recombinant protein
Artikelnummer: BPS-40039
Active recombinant full-length human CHK1 was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag. The gene accession number is NM_001274.
| Schlagworte: | CHK1, CHEK1, Checkpoint kinase-1, CHK1 checkpoint homolog, Cell cycle checkpoint kinase, Serine/threonine-protein kinase... |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 82 kD |
862,00 €
PF-477736
Artikelnummer: Cay17859-5
Checkpoint kinase 1 (Chk1) regulates S and G2-M phase cell cycle checkpoints in response to DNA damage. PF-477736 is an ATP-competitive inhibitor of Chk1 with a Ki value of 0.49 nM that demonstrates 100-fold selectivity over Chk2. When used in combination with various chemotherapeutics, PF-477736 abrogates DNA...
| Schlagworte: | (alphaR)-amino-N-[5,6-dihydro-2-(1-methyl-1H-pyrazol-4-yl)-6-oxo-1H-pyrrolo[4,3,2-ef][2,3]benzodiazepin-8-yl]-cyclohexanea... |
| Anwendung: | ATP-competitive Chk1 inhibitor |
| CAS | 952021-60-2 |
| MW: | 419.5 D |
ab 142,00 €
LY2606368
Artikelnummer: Cay21490-1
LY2606368 is a checkpoint kinase 1 (Chk1) inhibitor with a Ki value of 0.9 nM against the purified target and IC50 values of In vitro, LY2606368 inhibits the doxorubicin-activated G2/M checkpoint in p53-deficient HeLa cells with an EC50 value of 9 nM. LY2606368, at 25 nM, also significantly induces apoptosis and...
| Schlagworte: | Prexasertib, 5-[[5-[2-(3-aminopropoxy)-6-methoxyphenyl]-1H-pyrazol-3-yl]amino]-2-pyrazinecarbonitrile |
| Anwendung: | CHK1 inhibitor |
| CAS | 1234015-52-1 |
| MW: | 365.4 D |
ab 156,00 €
SCH 900776
Artikelnummer: Cay18131-500
Checkpoint kinase 1 (Chk1) regulates S and G2-M phase cell cycle checkpoints in response to DNA damage. SCH 900776 is a functionally selective inhibitor of Chk1 (Kd = 2 nM, IC50 = 3 nM). In comparison, 18-fold and 500-fold higher concentrations of this compound are required to inhibit CDK2 and Chk2. At 5-50 mg/kg,...
| Schlagworte: | MK-8776, 6-bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(3R)-3-piperidinyl-pyrazolo[1,5-a]pyrimidin-7-amine |
| Anwendung: | Chk1 inhibitor |
| CAS | 891494-63-6 |
| MW: | 376.3 D |
ab 61,00 €