GS-9620

GS-9620 is an orally available agonist of toll-like receptor 7 (TLR7, EC50 = 291 nM) with 30-fold selectivity over TLR8 (EC50 = 9 µM). It has been shown to stimulate a TLR7 immune response in two different animal models of chronic hepatitis B infection and to inhibit HIV-1 infection in human peripheral blood mononuclear cells.Formal Name: 4-amino-2-butoxy-7,8-dihydro-8-[[3-(1-pyrrolidinylmethyl)phenyl]methyl]-6(5H)-pteridinone. CAS Number: 1228585-88-3. Synonyms: Vesatolimod. Molecular Formula: C22H30N6O2. Formula Weight: 410.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMSO: 15 mg/ml, DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml. lambdamax: 214, 282 nm. SMILES: O=C(NC1=C2N=C(OCCCC)N=C1N)CN2CC3=CC(CN4CCCC4)=CC=C3. InChi Code: InChI=1S/C22H30N6O2/c1-2-3-11-30-22-25-20(23)19-21(26-22)28(15-18(29)24-19)14-17-8-6-7-16(12-17)13-27-9-4-5-10-27/h6-8,12H,2-5,9-11,13-15H2,1H3,(H,24,29)(H2,23,25,26). InChi Key: VFOKSTCIRGDTBR-UHFFFAOYSA-N.