Zu "K05404" wurden 78 Artikel gefunden!
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852A
Artikelnummer: Cay39512-1
852A is a toll-like receptor 7 (TLR7) agonist. It selectively induces NF-kappaB signaling in HEK293 cells expressing recombinant human TLR7 but not HEK293 cells expressing recombinant human TLR8 or TLR9 when used at a concentration of 1 µM. 852A (10-1,000 ng/ml) also induces IFN-alpha production in plasmacytoid...
| Schlagworte: | PF-4878691, N-[4-(4-amino-2-ethyl-1H-imidazo[4,5-c]quinolin-1-yl)butyl]-methanesulfonamide |
| Anwendung: | TLR7 agonist |
| CAS | 532959-63-0 |
| MW: | 361.5 D |
ab 54,00 €
Mouse TLR7 (Toll Like Receptor 7) ELISA Kit
Artikelnummer: ELK-ELK2700.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse TLR7. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse TLR7. Next,...
| Schlagworte: | Tlr7, Toll-like receptor 7 |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | mouse |
ab 365,00 €
Human TLR7 (Toll Like Receptor 7) ELISA Kit
Artikelnummer: ELK-ELK2701.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human TLR7. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human TLR7. Next,...
| Schlagworte: | Toll-like receptor 7 |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 365,00 €
CL097
Artikelnummer: Cay39513-1
CL097 is a dual agonist of toll-like receptor 7 (TLR7) and TLR8. It induces activation of NF-kappaB in HEK293 cells expressing human TLR7 or TLR8 when used at concentrations of 0.1 and 1 µg/ml, respectively. CL097 induces TNF-alpha production and enhances LPS- or hyaluronic acid-induced TNF-alpha, IL-10, and IL-12...
| Schlagworte: | 2-(ethoxymethyl)-3H-imidazo[4,5-c]quinolin-4-amine |
| Anwendung: | TLR7 / TLR8 dual agonist |
| CAS | 1026249-18-2 |
| MW: | 242.3 D |
ab 40,00 €
LHC165 (hydrate)
Artikelnummer: Cay38776-1
LHC165 is a toll-like receptor 7 (TLR7) agonist.Formal Name: 5-amino-2-[2-[4-[2-(3,3-difluoro-3-phosphonopropoxy)ethoxy]-2-methylphenyl]ethyl]-benzo[f][1,7]naphthyridine-8-propanoic acid, hydrate. Molecular Formula: C29H32F2N3O7P . XH2O. Formula Weight: 603.6. Purity: >95%. Formulation: (Request formulation change),...
| Schlagworte: | 5-amino-2-[2-[4-[2-(3,3-difluoro-3-phosphonopropoxy)ethoxy]-2-methylphenyl]ethyl]-benzo[f][1,7]naphthyridine-8-propanoic... |
| Anwendung: | TLR7 agonist |
| MW: | 603.6 D |
ab 582,00 €
Imiquimod
Artikelnummer: Cay14956-100
Imiquimod is an imidazoquinoline agonist of toll-like receptor 7 (TLR7, EC50 = 2.12 µM). It increases TNF-alpha and IL-12 p40 production in IFN-gamma-treated murine peritoneal macrophages in a concentration- and MyD88-dependent manner. Topical application of imiquimod (30 µl of 5% cream) increases TNF and IFN levels...
| Schlagworte: | R-837, S-26308, TMX 101, 1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine |
| Anwendung: | TLR7 activator |
| CAS | 99011-02-6 |
| MW: | 240.3 D |
ab 49,00 €
GS-9620
Artikelnummer: Cay19628-25
GS-9620 is an orally available agonist of toll-like receptor 7 (TLR7, EC50 = 291 nM) with 30-fold selectivity over TLR8 (EC50 = 9 µM). It has been shown to stimulate a TLR7 immune response in two different animal models of chronic hepatitis B infection and to inhibit HIV-1 infection in human peripheral blood...
| Schlagworte: | Vesatolimod, 4-amino-2-butoxy-7,8-dihydro-8-[[3-(1-pyrrolidinylmethyl)phenyl]methyl]-6(5H)-pteridinone |
| Anwendung: | TLR7 agonist |
| CAS | 1228585-88-3 |
| MW: | 410.5 D |
ab 84,00 €
1V209
Artikelnummer: Cay38318-10
1V209 is a benzoic acid-modified purine that, when conjugated to polysaccharides or sterols, acts as a toll-like receptor 7 (TLR7) agonist. A variety of 1V209-polysaccharide conjugates, but not 1V209 alone, increase TNF-alpha secretion from RAW 264.7 macrophages and IL-6 secretion from bone marrow-derived dendritic...
| Schlagworte: | TLR7 Agonist T7, Toll-Like Receptor 7 Agonist T7,... |
| Anwendung: | Benzoic-acid modified purine, TLR7 agonist precursor |
| CAS | 1062444-54-5 |
| MW: | 359.3 D |
ab 135,00 €
R-848
Artikelnummer: AG-CR1-3582-M005
Synthetic. Immune response modifier. Potent antitumor and antiviral compound. Stimulates antibody secretion and cytokine production. Used as adjuvant to increase the effectiveness of vaccines. Potent and selective synthetic ligand for Toll-like receptor 7 (TLR7) in mouse and for TLR7 and TLR8 in human. Activates...
| Schlagworte: | Resiquimod, S 28463, R848 |
| Anwendung: | TLR7 ligand |
| CAS | 144875-48-9 |
| MW: | 314,4 D |
ab 66,00 €
Gardiquimod
Artikelnummer: Cay18877-5
Gardiquimod is an agonist of human toll-like receptor 7 (TLR7), but not human TLR8, although it activates both porcine TLR7 and TLR8. At 0.5 to 2 µg/ml, it enhances the immunosuppressive activity of T regulatory cells. Gardiquimod is effective as a mucosal adjuvant for Norwalk virus-like particles and inhibits...
| Schlagworte: | 4-amino-2-[(ethylamino)methyl]-alpha,alpha-dimethyl-1H-imidazo[4,5-c]quinoline-1-ethanol |
| Anwendung: | TLR7 agonist |
| CAS | 1020412-43-4 |
| MW: | 313.4 D |
ab 66,00 €
Imiquimod
Artikelnummer: AG-CR1-3569-M250
Immune response modulator. Anti-inflammatory. TLR7 agonist. Stimulates proinflammatory cytokine production interferon-alpha (IFN-alpha), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) and activates NF-kappaB. Caspase-3 activator that directly induces procaspase-3 cleavage. Anti-cancer compound....
| Schlagworte: | 4-Amino-1-isobutyl-1H-imidazo(4,5-c)quinoline, S26308, R-837 |
| Anwendung: | TLR7 agonist |
| Wirt: | Synthetic |
| CAS | 99011-02-6 |
| MW: | 240,3 D |
ab 50,00 €
Imiquimod-d9
Artikelnummer: Cay26424-500
Imiquimod-d9 is intended for use as an internal standard for the quantification of imiquimod (Cay-14956) by GC- or LC-MS. Imiquimod is an imidazoquinoline agonist of toll-like receptor 7 (TLR7, EC50 = 2.12 µM). It increases TNF-alpha and IL-12 p40 production in IFN-gamma-treated murine peritoneal macrophages in a...
| Schlagworte: | 1-(2-(methyl-d3)propyl-1,1,2,3,3,3-d6)-1H-imidazo[4,5-c]quinolin-4-amine |
| Anwendung: | GC-MS, LC-MS, quantification, internal standard, TLR7 activator |
| CAS | 2712126-48-0 |
| MW: | 249.4 D |
ab 324,00 €