Erlotinib hydrochloride

Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. Erlotinib inhibits EGFR tyrosine kinase auto-phosphorylation. Studies in cell lines and enzyme assays have shown that erlotinib inhibits EGFR at concentrations significantly lower than those needed to inhibit c-src and v-abl. It has an IC(50) of 2nM against EGFR. It is >1000-fold more sensitive for EGFR than for c-Src or v-Abl. Target: EGFR , Kinase Group: RTK , Substrate: Tyrosine