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NEU
Anti-EGFRL858R Rabbit Monoclonal
Anti-EGFRL858R Rabbit Monoclonal

Artikelnummer: Cay32327-100

Epidermal growth factor receptor (EGFR), also known as HER1 and ErbB1, is a cell surface receptor and member of the EGF family of receptor tyrosine kinases with roles in cell proliferation, differentiation, and survival. It is a 170 kDa transmembrane receptor composed of an intracellular tyrosine kinase domain, a...
Schlagworte: Epidermal Growth Factor Receptor, ERBB1, Erb-B2 Receptor Tyrosine Kinase 1, HER1, Receptor Tyrosine-protein Kinase ErbB-1
Anwendung: IHC, WB
Reaktivität: Human
419,00 €
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NEU
AG-556
AG-556

Artikelnummer: Cay33335-10

AG-556 is a tyrphostin inhibitor of EGFR (IC50 = 5 µM). It is selective for EGFR over HER2 (IC50 = >500 µM). AG-556 inhibits EGF-induced growth of HER14 cells (IC50 = 3 µM). It inhibits hydrogen peroxide-induced increases in intracellular calcium in HEK293 cells expressing human transient receptor potential...
Schlagworte: Tyrphostin 56, Tyrphostin AG-556, (2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylbutyl)-2-propenamide
Anwendung: EGFR inhibitor
CAS 133550-41-1
MW: 336.4 D
ab 37,00 €
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Anti-EGF Receptor / EGFR
Anti-EGF Receptor / EGFR

Artikelnummer: NSJ-RQ5720

0.5mg/ml if reconstituted with 0.2ml sterile DI water. The epidermal growth factor receptor (EGFR, ErbB-1, HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. It is a member of the ErbB family of receptors, a subfamily of four...
Schlagworte: Anti-ERBB, EC=2.7.10.1, Anti-Proto-oncogene c-ErbB-1, Anti-Epidermal growth factor receptor, Anti-Receptor...
Anwendung: WB, IHC (paraffin), IF, FC, Direct ELISA
Reaktivität: Human
549,00 €
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Anti-EGF Receptor / EGFR
Anti-EGF Receptor / EGFR

Artikelnummer: NSJ-RQ5881

0.5mg/ml if reconstituted with 0.2ml sterile DI water. The epidermal growth factor receptor (EGFR, ErbB-1, HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. It is a member of the ErbB family of receptors, a subfamily of four...
Schlagworte: Anti-ERBB, EC=2.7.10.1, Anti-Proto-oncogene c-ErbB-1, Anti-Epidermal growth factor receptor, Anti-Receptor...
Anwendung: WB, IHC (paraffin), IF, FC, Direct ELISA
Reaktivität: Human, Mouse, Rat
549,00 €
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Anti-EGFR (C-Term) Rabbit
Anti-EGFR (C-Term) Rabbit

Artikelnummer: Cay32235-100

Epidermal growth factor receptor (EGFR), also known as HER1 and ErbB1, is a cell surface receptor and member of the EGF family of receptor tyrosine kinases with roles in cell proliferation, differentiation, and survival. It is a 170 kDa transmembrane receptor composed of an intracellular tyrosine kinase domain, a...
Schlagworte: Epidermal Growth Factor Receptor, ERBB, ERBB1, Erb-B2 Receptor Tyrosine Kinase 1, HER1, Receptor Tyrosine-protein Kinase...
Anwendung: IHC, WB
407,00 €
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Erlotinib
Erlotinib

Artikelnummer: Cay10483-250

Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity (IC50 = 2.5 µM). This inhibits tumor growth in human head and neck carcinoma HN5 tumor xenografts in mice with an ED50 value of 9 mg/kg. Erlotinib also suppresses...
Schlagworte: NSC 718781, N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine
Anwendung: Tyrosine kinase inhibitor
CAS 183321-74-6
MW: 393.4 D
ab 32,00 €
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EGFR (T790M, C797S, L858R), GST-tag
EGFR (T790M, C797S, L858R), GST-tag

Artikelnummer: BPS-40351

Human EGFR T790M, C797S, L858R (GenBank Accession No. NM_005228), (a.a. 668-1210) with N-terminal GST tag, MW = 88 kDa, expressed in baculovirus expression system.
Schlagworte: EGFR, ERBB, EC=2.7.10.1, Proto-oncogene c-ErbB-1, Epidermal growth factor receptor, Receptor tyrosine-protein kinase erbB-1
Anwendung: Enzyme kinetics, inhibitor screening, Selectivity profiling
Reaktivität: Human
MW: 88 kD
449,00 €
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Neratinib, Free Base
Neratinib, Free Base

Artikelnummer: LC-N-6404_100mg

Solubility: Soluble in DMSO at 2 mg/mL with warming, very poorly soluble in ethanol, very poorly soluble in water, maximum solubility in plain water is estimated to be about 5-20 µM, buffers, serum, or other additives may increase or decrease the aqueous solubility. Neratinib, also known as HKI-272, is considered to...
Schlagworte: HKI-272
Anwendung: EGFR/ ERBB2 inhibitor
CAS 698387-09-6
MW: 557,04 D
ab 62,00 €
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Osimertinib, Methanesulfonate Salt
Osimertinib, Methanesulfonate Salt

Artikelnummer: LC-O-7233_25mg

Soluble in DMSO. This research compound is the methanesulfonate salt form of osimertinib. Osimertinib, also known as AZD9291, is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI). EGFR TKIs have been used to treat patients with non-small-cell lung cancer (NSCLC) harboring sensitizing...
Schlagworte: AZD9291, Mereletinib
Anwendung: Antineoplastic, EGFR tyrosine kinase inhibitor
CAS 1421373-66-1
MW: 595.72 D
ab 76,00 €
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Anti-EGFR
Anti-EGFR

Artikelnummer: E-AB-66958.120

The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor...
Schlagworte: Anti-ERBB, EC=2.7.10.1, Anti-Proto-oncogene c-ErbB-1, Anti-Epidermal growth factor receptor, Anti-Receptor...
Anwendung: IF
Reaktivität: Human, Mouse, Rat
ab 117,00 €
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Vandetanib, Free Base
Vandetanib, Free Base

Artikelnummer: LC-V-9402_5g

Solubility: Soluble in DMSO at 30 mg/mL, soluble in ethanol at 10 mg/mL with warming, very poorly soluble in water, maximum solubility in plain water is estimated to be about 10-20 µM, buffers, serum, or other additives may increase or decrease the aqueous solubility. Vandetanib inhibits VEGFR-dependent tumor...
Schlagworte: ZD6474
Anwendung: Antineoplastic, Receptor tyrosine kinase inhibitor
CAS 1187431-43-1
MW: 475.35 D
ab 82,00 €
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Anti-EGF Receptor / EGFR, clone GFR/4563R
Anti-EGF Receptor / EGFR, clone GFR/4563R

Artikelnummer: NSJ-V8745-100UG

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. This MAb recognizes a protein of 170kDa, identified as EGFR. EGFR is type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2, -3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a...
Schlagworte: Anti-ERBB, EC=2.7.10.1, Anti-Proto-oncogene c-ErbB-1, Anti-Epidermal growth factor receptor, Anti-Receptor...
Anwendung: IHC (paraffin)
Reaktivität: Human
ab 263,00 €
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