Zu "K04361" wurden 956 Artikel gefunden!
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Erlotinib
Artikelnummer: Cay10483-250
Erlotinib is an EGFR inhibitor (Ki = 2.7 nM). It is greater than 1,000-fold selective for EGFR over Src and Abl at 0.1 µM. Erlotinib induces caspase-3 and -7 activity in NCI H358 non-small cell lung cancer (NSCLC) cells when used at a concentration of 1 µM. Erlotinib (25 mg/kg) reduces EGF-induced EGFR...
| Schlagworte: | NSC 718781, N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine |
| Anwendung: | Tyrosine kinase inhibitor |
| CAS | 183321-74-6 |
| MW: | 393.4 D |
ab 51,00 €
NEU
EGFR Protein, Human, Recombinant (CHO, His)
Artikelnummer: TGM-TMPS-00022-100ug
Description: EGFR Protein, Human, Recombinant (CHO, His) is expressed in CHO Cells. The accession number is P00533-1.
| Schlagworte: | HER1 , ERBB1 , ERBB |
| MW: | 115 kD |
ab 93,00 €
NEU
EGFR Protein, Human, Recombinant (His), AF488-Labeled
Artikelnummer: TGM-TMPY-06990-100ug
Description: EGFR Protein, Human, Recombinant (His), AF488-Labeled is expressed in HEK293 Cells. The accession number is P00533.
| Schlagworte: | PIG61 , mENA , ERBB , ERRP , NISBD2 , ERBB1 , HER1 |
| MW: | 72 kD |
ab 153,00 €
NEU
AG-112
Artikelnummer: Cay45208-10
An EGFR inhibitor, inhibits EGFR-catalyzed phosphorylation of poly(GAT) in a cell-free assay (IC50 = 0.125 µM), inhibits calcineurin phosphatase activity in a cell-free assay (IC50 = 30 µM), inhibits diabetes-induced growth of VSMCs isolated from type 2 diabetic rats, reduces diabetes-induced increases in superoxide...
| Schlagworte: | 2-amino-3-[(4-hydroxyphenyl)methylene]-1-propene-1,1,3-tricarbonitrile |
| Anwendung: | EGFR inhibitor |
| CAS | 144978-82-5 |
| MW: | 236.23 D |
ab 70,00 €
NEU
PROTAC EGFR Degrader 9
Artikelnummer: Cay45393-1
A PROTAC that drives mutant EGFR degradation, selectively induces degradation of mutant EGFRs over wild-type EGFR (DC50s = 10.2, 36.5, 88.5, 75.4, and >300 nM for EGFRL858R/T790M/C797S, EGFRDelta19/T790M/C797S, EGFRL858R/T790M, EGFRDelta19, and wild-type EGFR, respectively), inhibits the growth of H1975 cells...
| Schlagworte: | Proteolysis-targeting Chimera EGFR Degrader-9, Proteolysis-targeting Chimera Epidermal Growth Factor Receptor Degrader-9,... |
| Anwendung: | Mutant EGFR degradation driving PROTAC |
| CAS | 2992670-33-2 |
| MW: | 899.99 D |
ab 271,00 €
Limertinib
Artikelnummer: Cay45141-1
An inhibitor of mutant EGFR, selective for EGFRL858R/T790M, EGFRT790M, and EGFR containing an exon 19 deletion (IC50s = 0.3, 0.5, and 0.5 nM, respectively) over wild-type EGFR (IC50 = 6 nM) and a panel of 258 kinases at 100 nM, inhibits BTK and Itk (IC50s = 2.1 and 0.4 nM, respectively), selectively inhibits the...
| Schlagworte: | ASK120067,... |
| Anwendung: | Mutant EGFR inhibitor |
| CAS | 1934259-00-3 |
| MW: | 546.07 D |
ab 49,00 €
AG-537
Artikelnummer: Cay45255-1
A dimeric tyrphostin EGFR inhibitor (IC50 = 0.4 µM), selective for EGFR over the Bcr-Abl fusion proteins p210 and p185 and wild-type c-Abl (IC50s = 44, >100, and >100 µM, respectively, for the human proteins), inhibits EGFR autophosphorylation (IC50 = 3.3 µM), inhibits EGF-dependent proliferation of HER-14...
| Schlagworte: | Tyrphostin 537, Tyrphostin AG 537, (2E,2'E)-N,N'-1,3-propanediylbis[2-cyano-3-(3,4-dihydroxyphenyl)-2-propenamide |
| Anwendung: | Dimeric tyrphostin EGFR inhibitor |
| CAS | 140674-77-7 |
| MW: | 448.44 D |
ab 35,00 €
STX-721
Artikelnummer: Cay44459-1
STX-721 is an irreversible inhibitor of EGFR with an exon 20 insertion (ex20ins) mutation. It selectively inhibits the proliferation of Ba/F3 cells expressing EGFR exon20 A769_V770 insASV and EGFR exon20 D770_N771 insSVD (IC50s = 5. and 5. nM, respectively) over those expressing wild-type EGFR (IC50 = 127. nM)....
| Schlagworte: | 3-[(3-chloro-2-methoxyphenyl)amino]-2-[3-[2-[(2R)-1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]-2-methyl-2-pyrrolidinyl]et... |
| Anwendung: | Irreversible EGFR ex20ins inhibitor |
| CAS | 2765525-82-2 |
| MW: | 587.12 D |
ab 139,00 €
Befotertinib (mesylate)
Artikelnummer: Cay44845-1
Befotertinib is an inhibitor of mutant EGFRs. It selectively inhibits EGFRL858R, EGFRE709K, EGFRG719A, and EGFRL861Q (IC50s = 0. 14, 1. and 13 nM, respectively), as well as EGFR containing an exon 19 deletion and EGFR containing an exon 18 deletion (IC50s = 0. and 24 nM, respectively), over wild-type EGFR (IC50 =...
| Schlagworte: | D-0316,... |
| Anwendung: | Mutant EGFR inhibitor |
| CAS | 2226167-02-6 |
| MW: | 663.72 D |
ab 64,00 €
BMS 690514
Artikelnummer: Cay44552-1
BMS 690514 is a pan-inhibitor of HER and VEGFR family kinases (IC50s = 5, 19, 60, 50, 50, and 25 nM for EGFR, HER2, HER4, VEGFR1, VEGFR2, and VEGFR3, respectively). It is selective for these kinases over 11 additional kinases but also inhibits FMS-related tyrosine kinase 3 (FLT3), calcium/calmodulin-dependent...
| Schlagworte: | (3R,4R)-4-amino-1-[[4-[(3-methoxyphenyl)amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]methyl]-3-piperidinol |
| Anwendung: | HER / VEGFR family kinase pan-inhibitor |
| CAS | 859853-30-8 |
| MW: | 368.44 D |
ab 59,00 €
Oritinib
Artikelnummer: Cay45042-1
Oritinib is an inhibitor of mutant EGFR. It selectively inhibits EGFRL858R, EGFRL858R/T790M, EGFRDelta746-750, and EGFRDelta746-750/T790M (IC50s = 0. 0. 1. and 0. nM, respectively) over wild-type EGFR (IC50 = 18 nM). In vivo, oritinib (2. 5, and 15 mg/kg) inhibits tumor growth in PC-9 and H1975 mouse xenograft...
| Schlagworte: | SH-1028, N-[2-[[2-(dimethylamino)ethyl]methylamino]-4-... |
| Anwendung: | Mutant EGFR inhibitor |
| CAS | 2035089-28-0 |
| MW: | 539.68 D |
ab 139,00 €
Sevabertinib
Artikelnummer: Cay44586-1
Sevabertinib is a dual inhibitor of wild-type and exon 20 insertion (ex20ins) mutation-containing EGFR and HER2 (IC50s = 98%. Formulation (Request formulation change): A solid. Solubility: DMSO: Soluble: >10 mg/ml Ethanol: Sparingly soluble: 1-10 mg/ml. SMILES:...
| Schlagworte: | BAY-2927088,... |
| Anwendung: | Wild-type / ex20ins mutation-containing EGFR / HER2 dual inhibitor |
| CAS | 2521285-05-0 |
| MW: | 484.94 D |
ab 49,00 €