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Zu "K04361" wurden 712 Artikel gefunden!
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NEU
Artikelnummer: CR-C10021-100UG
Storage buffer: Azide free-phosphate buffered saline, 0.2 µm filter sterilized. Protein function: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:2790960, PubMed:10805725, PubMed:27153536)....
Schlagworte: | Anti-ERBB, EC=2.7.10.1, Anti-Proto-oncogene c-ErbB-1, Anti-Epidermal growth factor receptor, Anti-Receptor... |
Anwendung: | ELISA, FC, IHC, IF |
Wirt: | Human |
Spezies-Reaktivität: | Human |
ab 392,00 €
Artikelnummer: Cay10483-250
Erlotinib is an EGFR inhibitor (Ki = 2.7 nM). It is greater than 1,000-fold selective for EGFR over Src and Abl at 0.1 µM. Erlotinib induces caspase-3 and -7 activity in NCI H358 non-small cell lung cancer (NSCLC) cells when used at a concentration of 1 µM. Erlotinib (25 mg/kg) reduces EGF-induced EGFR...
Schlagworte: | NSC 718781, N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine |
Anwendung: | Tyrosine kinase inhibitor |
CAS | 183321-74-6 |
MW: | 393.4 D |
ab 43,00 €
Artikelnummer: Cay40753-1
AZ 7550 is an active metabolite of AZ 9291 (Cay-16237). It inhibits the insulin-like growth factor 1 receptor (IGF-1R) in a cell-free assay (IC50 = 1.6 µM). It inhibits EGFR autophosphorylation in H1975 and PC-9 cells expressing the respective constitutively active mutants EGFRT790M/L858R and EGFRExon19del (IC50s =...
Schlagworte: | N-[4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]-2-[methyl[2-(methylamino)ethyl]amino]phenyl]-2-propenamid... |
Anwendung: | AZ 9291 active metabolite, mutant-selective EGFR inhibitor |
MW: | 485.6 D |
ab 34,00 €
Artikelnummer: Cay27911-10
TAS 6417 is a pan-EGFR inhibitor. It inhibits wild-type EGFR (IC50= 8 nM), as well as the EGFR point mutants EGFRL858R, EGFRL861Q, EGFRT790M, EGFRT790M/L858R (IC50s = 1.9, 5.5, 4.1, and 2 nM, respectively) and the insertion or deletion mutants EGFR D770_N771insNPG, EGFR d746-750, and EGFR d746-770/T790M (IC50s =...
Schlagworte: | CLN-081, Zipalertinib, N-[(8S)-4-amino-8,9-dihydro-6-methyl-5-(3-quinolinyl)pyrimido[5,4-b]indolizin-8-yl]-2-propenamide |
Anwendung: | Pan-EGFR inhibitor |
CAS | 1661854-97-2 |
MW: | 396.4 D |
ab 74,00 €
Artikelnummer: Cay38900-1
DZD9008 is an irreversible inhibitor of EGFR containing a lysine-to-arginine mutation at position 858 and T790M (EGFRL858R,T790M, IC50 = 1.1 nM). It is selective for EGFRL858R,T790M over Bruton's tyrosine kinase (BTK), wild-type EGFR, focal adhesion kinase (FAK), HER2, and HER4 (IC50s = 213, 226, 255, 392, and 704...
Schlagworte: | N-[5-[[4-[[5-chloro-4-fluoro-2-(1-hydroxy-1-methylethyl)phenyl]amino]-2-pyrimidinyl]amino]-2-[(3S)-3-(dimethylamino)-1-pyr... |
Anwendung: | EGFR(L858R) inhibitor |
CAS | 2370013-49-1 |
MW: | 584.1 D |
ab 66,00 €
Artikelnummer: BPS-40351
Human EGFR T790M, C797S, L858R (GenBank Accession No. NM_005228), (a.a. 668-1210) with N-terminal GST tag, MW = 88 kDa, expressed in baculovirus expression system.
Schlagworte: | ERBB, EC=2.7.10.1, Proto-oncogene c-ErbB-1, Epidermal growth factor receptor, Receptor tyrosine-protein kinase erbB-1,... |
Anwendung: | Enzyme kinetics, inhibitor screening, selectivity profiling |
Ursprungsart: | human |
MW: | 88 kD |
540,00 €
Artikelnummer: REV-31-1385-00-R100
EGFR (Epidermal growth factor receptor, HER1, ErbB1) belongs to the HER/ERbB family of proteins that includes three other receptor tyrosine kinases, ERbB2, ERbB3, ERbB4. EGFR is a transmembrane receptor and binding of its cognate ligands such as EGF (Epidermal Growth Factor) and TGF alpha (Transforming Growth Factor...
Schlagworte: | Anti-ERBB, EC=2.7.10.1, Anti-Proto-oncogene c-ErbB-1, Anti-Epidermal growth factor receptor, Anti-Receptor... |
Anwendung: | IHC, WB |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
483,00 €
Artikelnummer: BPS-100187
Recombinant human EGFR (epidermal growth factor receptor) encompassing tyrosine kinase domain amino acids 668-1210(end) with a deletion of amino acids 746 to 750 and mutations T790M and C797S. This construct contains an N-terminal GST-tag and a C-terminal His-tag (6xHis). This protein was affinity purified.
Schlagworte: | ERBB, EC=2.7.10.1, Proto-oncogene c-ErbB-1, Epidermal growth factor receptor, Receptor tyrosine-protein kinase erbB-1,... |
Anwendung: | Enzyme kinetics, inhibitor screening, selectivity profiling |
Ursprungsart: | human |
MW: | 87 kD |
796,00 €
Artikelnummer: ELK-ELK2110.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human EGFR. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human EGFR. Next,...
Schlagworte: | ERBB, EC=2.7.10.1, Proto-oncogene c-ErbB-1, Epidermal growth factor receptor, Receptor tyrosine-protein kinase erbB-1 |
Anwendung: | ELISA |
Spezies-Reaktivität: | human |
ab 365,00 €
Artikelnummer: ELK-ELK2421.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse EGFR. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse EGFR. Next,...
Schlagworte: | EC=2.7.10.1, Epidermal growth factor receptor |
Anwendung: | ELISA |
Spezies-Reaktivität: | mouse |
ab 365,00 €
Artikelnummer: Cay13166-250
Gefitinib is an EGFR inhibitor (IC50s = 0.023-0.079 µM). It inhibits colony formation of GEO colon, ZR-75-1 and MCF-10A breast, and OVCAR-3 ovarian cancer cell lines in soft agar assays (IC50s = 0.2-0.4 µM). Gefitinib (0.1 to 1 µM) induces apoptosis and inhibits EGFR autophosphorylation in the same cells. In vivo,...
Schlagworte: | ZD 1839, N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine |
Anwendung: | EGFR-TK inhibitor |
CAS | 184475-35-2 |
MW: | 446.9 D |
ab 100,00 €
Artikelnummer: G-IVMB0238.1
Endotoxin level: < 1.0 EU/mg as determined by the LAL method. Protein function: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:2790960, PubMed:10805725, PubMed:27153536). Known ligands...
Schlagworte: | Anti-ERBB, EC=2.7.10.1, Anti-Proto-oncogene c-ErbB-1, Anti-Epidermal growth factor receptor, Anti-Receptor... |
Anwendung: | WB, CyTOF, ELISA, FC, ICC, IHC |
Wirt: | Human |
Spezies-Reaktivität: | human |
ab 288,00 €