BTSA1

BTSA1 is an activator of Bax. It binds to the Bax N-terminal activation site, also known as the trigger site (IC50 = 250 nM), and induces Bax translocation membrane permeabilization in liposomes when used at concentrations ranging from 100 to 400 nM. BTSA1 (0.1-1 µM) induces apoptosis in various human and mouse acute myeloid leukemia (AML) cell lines. In vivo, BTSA (10 mg/kg) reduces bone marrow infiltration and promotes apoptosis in bone marrow infiltrates in a MOLM-13 AML mouse xenograft model.Formal Name: 3-phenyl-1-(4-phenyl-2-thiazolyl)-1H-pyrazole-4,5-dione, 4-[2-(2-thiazolyl)hydrazone]. CAS Number: 314761-14-3. Synonyms: Bax Trigger Site Activator 1. Molecular Formula: C21H14N6OS2. Formula Weight: 430.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10 mg/ml, DMSO: 2 mg/ml, Ethanol: Slightly soluble. lambdamax: 249 nm. SMILES: O=C1N(C2=NC(C3=CC=CC=C3)=CS2)N=C(C4=CC=CC=C4)C1=NNC5=NC=CS5. InChi Code: InChI=1S/C21H14N6OS2/c28-19-18(24-25-20-22-11-12-29-20)17(15-9-5-2-6-10-15)26-27(19)21-23-16(13-30-21)14-7-3-1-4-8-14/h1-13H,(H,22,25). InChi Key: KYVZVVOQWWCVPP-UHFFFAOYSA-N.